C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: PTK2 protein tyrosine kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022607 Ptk2 10090 - 15:73205105-73423191 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000110036 Ptk2-201 73205105-73423191 protein_coding
  ENSMUST00000170939 Ptk2-202 73215557-73423191 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000110036ENSMUST00000170939
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000110036 8.384±0.69 4.252±1.12 6.954±2.51 14.392±4.21 3.853±1.19 4.916±2.21 2.519±0.44 4.928±1.43 3.409±1.46 10.675±0.19 4.443±0.79 9.820±3.59 17.411±6.17 3.995±3.20
ENSMUST00000170939 N/A N/A N/A N/A N/A N/A 0.903±0.00 N/A N/A N/A N/A 2.336±0.89 N/A 3.624±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XD CIL_0002XD_0002 CGP 15:73095844-73423191
CIL_0006FQ CIL_0006FQ_0003 CGP 15:73205105-73572242

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000226 IDA microtubule cytoskeleton organization
GO:0001525 IMP angiogenesis
GO:0001568 IMP blood vessel development
GO:0001570 IMP vasculogenesis
GO:0001725 IEA stress fiber
GO:0001764 IDA neuron migration
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0003779 IEA actin binding
GO:0004713 IDA protein tyrosine kinase activity
GO:0004715 ISS non-membrane spanning protein tyrosine kinase activity
GO:0004871 IEA signal transducer activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005925 IDA focal adhesion
GO:0006928 TAS cellular component movement
GO:0007172 IEA signal complex assembly
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007229 ISS integrin-mediated signaling pathway
GO:0008284 IMP positive regulation of cell proliferation
GO:0008360 ISS regulation of cell shape
GO:0008432 IEA JUN kinase binding
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016324 IDA apical plasma membrane
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0021955 IMP central nervous system neuron axonogenesis
GO:0022408 IEA negative regulation of cell-cell adhesion
GO:0030027 IDA lamellipodium
GO:0030198 IMP extracellular matrix organization
GO:0030335 ISS positive regulation of cell migration
GO:0033628 ISS regulation of cell adhesion mediated by integrin
GO:0040023 IDA establishment of nucleus localization
GO:0042127 ISS regulation of cell proliferation
GO:0042169 IEA SH2 domain binding
GO:0043066 ISS negative regulation of apoptotic process
GO:0043542 IMP endothelial cell migration
GO:0045667 ISS regulation of osteoblast differentiation
GO:0045860 ISS positive regulation of protein kinase activity
GO:0046621 IGI negative regulation of organ growth
GO:0046777 IMP protein autophosphorylation
GO:0048013 ISS ephrin receptor signaling pathway
GO:0050771 IMP negative regulation of axonogenesis
GO:0051897 ISS positive regulation of protein kinase B signaling
GO:0051964 IMP negative regulation of synapse assembly
GO:0060396 IEA growth hormone receptor signaling pathway
GO:2000060 IMP positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811 IEA negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004672 ptk2.1 protein tyrosine kinase 2a protein_coding Danio_rerio
ENSDARG00000040197 ptk2.2 protein tyrosine kinase 2b protein_coding Danio_rerio
ENSG00000169398 PTK2 protein tyrosine kinase 2 protein_coding Homo_sapiens

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