C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022897 Dyrk1a 10090 + 16:94570010-94695517 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000023614 Dyrk1a-201 94570907-94695517 protein_coding
  ENSMUST00000119878 Dyrk1a-001 94570010-94695067 protein_coding
  ENSMUST00000122284 Dyrk1a-002 94570479-94692201 protein_coding
  ENSMUST00000134383 Dyrk1a-005 94668896-94679521 retained_intron
  ENSMUST00000139250 Dyrk1a-003 94570864-94665947 protein_coding
  ENSMUST00000155791 Dyrk1a-004 94570907-94668831 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023614ENSMUST00000119878ENSMUST00000122284ENSMUST00000155791
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023614 N/A 3.125±0.26 N/A N/A 4.915±1.19 4.145±0.00 N/A N/A 1.116±0.23 3.661±0.00 N/A 4.479±2.09 N/A N/A
ENSMUST00000119878 6.800±2.14 2.162±0.24 3.795±0.48 11.637±0.35 5.235±1.27 5.238±1.72 6.729±0.32 4.923±0.67 3.771±2.23 7.683±0.97 4.438±0.66 6.817±2.31 8.900±2.04 2.921±0.89
ENSMUST00000122284 8.269±0.89 11.996±1.53 N/A 8.757±1.11 14.205±1.62 11.330±2.12 6.216±0.33 7.096±1.93 4.272±1.27 11.095±2.78 N/A 14.054±4.81 11.193±1.78 3.886±0.97
ENSMUST00000155791 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.915±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001CZ CIL_0001CZ_0003 CGP 16:94497783-94695517
CIL_0006ZG CIL_0006ZG_0002 CGP 16:94570010-94997696

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000381 IEA regulation of alternative mRNA splicing, via spliceosome
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004712 IEA protein serine/threonine/tyrosine kinase activity
GO:0004713 ISS protein tyrosine kinase activity
GO:0004715 ISO non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0006468 ISS protein phosphorylation
GO:0007623 IMP circadian rhythm
GO:0016607 ISS nuclear speck
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0018108 ISO:ISS peptidyl-tyrosine phosphorylation
GO:0030529 IDA ribonucleoprotein complex
GO:0042802 IPI identical protein binding
GO:0043518 IDA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043621 IPI protein self-association
GO:0046777 ISS protein autophosphorylation
GO:0048156 IPI tau protein binding
GO:0090312 IDA positive regulation of protein deacetylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000063570 dyrk1aa dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a protein_coding Danio_rerio
ENSG00000157540 DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A protein_coding Homo_sapiens

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