C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000157540 DYRK1A 9606 + 21:37365790-37517450 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000338785 DYRK1A-001 37367577-37515377 protein_coding
  ENST00000339659 DYRK1A-003 37418905-37517450 protein_coding
  ENST00000398956 DYRK1A-008 37420375-37511954 protein_coding
  ENST00000398960 DYRK1A-006 37420300-37512586 protein_coding
  ENST00000426672 DYRK1A-005 37367581-37480705 protein_coding
  ENST00000455097 DYRK1A-004 37367581-37472811 protein_coding
  ENST00000462274 DYRK1A-002 37366934-37486481 processed_transcript
  ENST00000498351 DYRK1A-007 37420325-37472715 processed_transcript
  ENST00000608928 DYRK1A-009 37365790-37420385 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000338785ENST00000339659ENST00000398960ENST00000462274
Transcript ID Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000338785 2.913±0.00 7.071±0.00 6.617±0.00 4.186±0.00 3.467±0.00 1.799±0.00 4.832±1.25 7.563±0.00 1.966±0.00 9.132±4.94 6.289±1.71 9.419±6.23
ENST00000339659 0.520±0.00 N/A 1.463±0.00 1.187±0.00 0.426±0.00 N/A 1.299±0.00 1.641±0.00 N/A 1.601±0.00 N/A N/A
ENST00000398960 2.413±0.00 6.138±0.00 N/A 2.127±0.00 1.843±0.00 1.900±0.00 N/A N/A 4.147±0.00 N/A N/A 5.972±0.00
ENST00000462274 N/A 13.339±0.00 N/A 8.327±0.00 6.796±0.00 N/A 16.630±0.00 9.655±0.00 15.299±0.00 19.916±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001CZ CIL_0001CZ_0002 CGP 21:37223420-37517450
CIL_0006ZG CIL_0006ZG_0001 CGP 21:37365790-37916446

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000278 TAS mitotic cell cycle
GO:0000381 IEA regulation of alternative mRNA splicing, via spliceosome
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004712 IEA protein serine/threonine/tyrosine kinase activity
GO:0004713 ISS:IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0006468 ISS:IEA protein phosphorylation
GO:0007399 TAS nervous system development
GO:0007623 ISS circadian rhythm
GO:0016607 ISS nuclear speck
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0018107 ISS peptidyl-threonine phosphorylation
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0030529 IEA ribonucleoprotein complex
GO:0042802 IEA identical protein binding
GO:0043518 ISS negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043621 ISS protein self-association
GO:0046777 ISS protein autophosphorylation
GO:0048156 ISS tau protein binding
GO:0090312 ISS positive regulation of protein deacetylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000063570 dyrk1aa dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a protein_coding Danio_rerio
ENSMUSG00000022897 Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a protein_coding Mus_musculus

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