C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000119878 Dyrk1a-001 ENSMUSG00000022897 10090 + 16:94570010-94695067 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000119878
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000119878 6.800±2.14 2.162±0.24 3.795±0.48 11.637±0.35 5.235±1.27 5.238±1.72 6.729±0.32 4.923±0.67 3.771±2.23 7.683±0.97 4.438±0.66 6.817±2.31 8.900±2.04 2.921±0.89

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001CZ CIL_0001CZ_0003 CGP 16:94497783-94695517
CIL_0006ZG CIL_0006ZG_0002 CGP 16:94570010-94997696

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000381 IEA regulation of alternative mRNA splicing, via spliceosome
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004712 IEA protein serine/threonine/tyrosine kinase activity
GO:0004713 ISS protein tyrosine kinase activity
GO:0004715 ISO non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0006468 ISS protein phosphorylation
GO:0007623 IMP circadian rhythm
GO:0016607 ISS nuclear speck
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0018108 ISO:ISS peptidyl-tyrosine phosphorylation
GO:0030529 IDA ribonucleoprotein complex
GO:0042802 IPI identical protein binding
GO:0043518 IDA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043621 IPI protein self-association
GO:0046777 ISS protein autophosphorylation
GO:0048156 IPI tau protein binding
GO:0090312 IDA positive regulation of protein deacetylation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000100073 dyrk1aa-201 protein_coding Danio_rerio 0 863
ENSDART00000144722 dyrk1aa-002 protein_coding Danio_rerio 0 401
ENSDART00000141723 dyrk1aa-001 protein_coding Danio_rerio 0 361
ENSDART00000147674 dyrk1aa-004 processed_transcript Danio_rerio 2e-32 147
ENST00000338785 DYRK1A-001 protein_coding Homo_sapiens 0 3530
ENST00000339659 DYRK1A-003 protein_coding Homo_sapiens 0 5629
ENST00000398956 DYRK1A-008 protein_coding Homo_sapiens 0 2313
ENST00000398960 DYRK1A-006 protein_coding Homo_sapiens 0 3703
ENST00000426672 DYRK1A-005 protein_coding Homo_sapiens 0 854
ENST00000455097 DYRK1A-004 protein_coding Homo_sapiens 0 363
ENST00000462274 DYRK1A-002 processed_transcript Homo_sapiens 0 573
ENST00000498351 DYRK1A-007 processed_transcript Homo_sapiens 2e-23 111
ENST00000608928 DYRK1A-009 processed_transcript Homo_sapiens 4e-39 165

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