C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: twinfilin, actin-binding protein, homolog 2 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000023277 Twf2 10090 + 9:106203108-106215389 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000024047 Twf2-001 106203108-106215389 protein_coding
  ENSMUST00000187647 Twf2-004 106203145-106212819 nonsense_mediated_decay
  ENSMUST00000187944 Twf2-002 106203137-106212256 nonsense_mediated_decay
  ENSMUST00000188650 Twf2-003 106206798-106215387 protein_coding
  ENSMUST00000189708 Twf2-005 106214228-106215021 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000024047ENSMUST00000187647ENSMUST00000188650ENSMUST00000189708
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000024047 15.893±2.20 28.146±8.47 11.844±1.66 15.105±3.23 19.983±8.62 9.169±1.83 N/A 5.587±1.86 7.094±6.33 16.857±1.55 N/A 15.205±6.52 20.269±5.49 3.301±1.45
ENSMUST00000187647 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.187±0.00
ENSMUST00000188650 3.476±1.02 17.854±7.00 N/A N/A 15.629±9.38 5.604±0.75 80.465±20.47 5.207±2.28 1.022±0.31 8.870±1.28 73.570±8.97 7.541±2.49 8.868±4.74 2.047±0.87
ENSMUST00000189708 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 10.355±0.00 11.579±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008NT CIL_0008NT_0002 VISTA 9:106082995-106685663
CIL_00087C CIL_00087C_0002 VISTA 9:106116951-106718793

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003785 IDA actin monomer binding
GO:0005080 ISA protein kinase C binding
GO:0005524 ISA ATP binding
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 ISA cytoplasm
GO:0005856 IEA cytoskeleton
GO:0010592 IEA positive regulation of lamellipodium assembly
GO:0010976 IEA positive regulation of neuron projection development
GO:0030016 IDA myofibril
GO:0030027 IDA lamellipodium
GO:0030030 IEA cell projection organization
GO:0030175 IDA filopodium
GO:0030426 IEA growth cone
GO:0030837 IDA negative regulation of actin filament polymerization
GO:0032420 IDA stereocilium
GO:0032532 IC regulation of microvillus length
GO:0032956 IEA regulation of actin cytoskeleton organization
GO:0035556 ISA intracellular signal transduction
GO:0042989 IDA sequestering of actin monomers
GO:0044822 IEA poly(A) RNA binding
GO:0045773 IEA positive regulation of axon extension
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051016 IDA barbed-end actin filament capping
GO:0070062 IEA extracellular vesicular exosome
GO:0071300 IEA cellular response to retinoic acid
GO:0071363 IEA cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009727 twf2b twinfilin, actin-binding protein, homolog 2b (Drosophila) protein_coding Danio_rerio
ENSG00000247596 TWF2 twinfilin actin-binding protein 2 protein_coding Homo_sapiens

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