C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SRY (sex determining region Y)-box 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024176 Sox8 10090 - 17:25565892-25570686 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025003 Sox8-001 25565892-25570686 protein_coding
  ENSMUST00000173447 Sox8-002 25568710-25570686 protein_coding
  ENSMUST00000174560 Sox8-003 25567988-25570214 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025003ENSMUST00000173447ENSMUST00000174560
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025003 0.315±0.09 0.580±0.19 0.414±0.10 7.227±2.96 0.963±0.51 0.668±0.29 0.193±0.06 0.351±0.04 0.041±0.04 0.232±0.03 0.175±0.05 1.665±0.82 1.409±1.71 3.124±0.80
ENSMUST00000173447 N/A 0.463±0.07 0.365±0.00 N/A 0.659±0.00 0.300±0.00 N/A N/A 0.026±0.01 N/A 0.097±0.00 1.385±0.00 N/A N/A
ENSMUST00000174560 N/A N/A N/A N/A N/A N/A N/A N/A 0.078±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000U6 CIL_0000U6_0002 CGP 17:25565892-25662826

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001649 IMP osteoblast differentiation
GO:0001701 IGI in utero embryonic development
GO:0001755 IMP neural crest cell migration
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007165 IMP signal transduction
GO:0007283 IMP spermatogenesis
GO:0007422 IGI peripheral nervous system development
GO:0008134 IPI transcription factor binding
GO:0008584 IGI male gonad development
GO:0010628 IGI positive regulation of gene expression
GO:0010817 IMP regulation of hormone levels
GO:0014015 IMP positive regulation of gliogenesis
GO:0033690 IMP positive regulation of osteoblast proliferation
GO:0035914 IMP skeletal muscle cell differentiation
GO:0043066 IMP negative regulation of apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0044798 IDA nuclear transcription factor complex
GO:0045165 IGI cell fate commitment
GO:0045444 IMP fat cell differentiation
GO:0045662 IDA negative regulation of myoblast differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046533 IGI negative regulation of photoreceptor cell differentiation
GO:0046982 IDA protein heterodimerization activity
GO:0048469 IGI cell maturation
GO:0048484 IMP enteric nervous system development
GO:0048709 IMP oligodendrocyte differentiation
GO:0060009 IEP Sertoli cell development
GO:0060018 IGI astrocyte fate commitment
GO:0060041 IGI retina development in camera-type eye
GO:0060221 IGI retinal rod cell differentiation
GO:0060612 IMP adipose tissue development
GO:0061138 IGI morphogenesis of a branching epithelium
GO:0072034 IMP renal vesicle induction
GO:0072197 IGI ureter morphogenesis
GO:0072289 IGI metanephric nephron tubule formation
GO:0090184 IGI positive regulation of kidney development
GO:0090190 IMP positive regulation of branching involved in ureteric bud morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037782 sox8b SRY (sex determining region Y)-box 8b protein_coding Danio_rerio
ENSDARG00000043923 sox9b SRY-box containing gene 9b protein_coding Danio_rerio
ENSDARG00000068019 sox8a SRY (sex determining region Y)-box 8a protein_coding Danio_rerio
ENSG00000005513 SOX8 SRY (sex determining region Y)-box 8 protein_coding Homo_sapiens

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