C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024451 Arap3 10090 - 18:37972624-37997574 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000042944 Arap3-201 37972624-37997574 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000042944
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000042944 10.201±6.25 5.830±0.99 1.559±0.09 1.542±0.85 7.496±0.69 2.631±1.17 10.206±2.12 4.445±1.49 3.012±1.53 41.175±2.79 3.514±0.63 2.849±1.40 5.646±4.84 0.233±0.10

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002P1 CIL_0002P1_0002 CGP 18:37957431-37997574
CIL_0006QH CIL_0006QH_0002 CGP 18:37972624-38212053

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 IDA ruffle
GO:0005100 IDA Rho GTPase activator activity
GO:0005515 IPI protein binding
GO:0005547 IEA phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005737 IDA cytoplasm
GO:0005856 IEA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0007165 IEA signal transduction
GO:0008060 IDA ARF GTPase activator activity
GO:0008270 IEA zinc ion binding
GO:0008360 IDA regulation of cell shape
GO:0030027 IDA lamellipodium
GO:0030336 IDA negative regulation of cell migration
GO:0032312 IEA regulation of ARF GTPase activity
GO:0032321 IDA positive regulation of Rho GTPase activity
GO:0035021 IDA negative regulation of Rac protein signal transduction
GO:0035024 IDA negative regulation of Rho protein signal transduction
GO:0043325 IEA phosphatidylinositol-3,4-bisphosphate binding
GO:0043547 IDA positive regulation of GTPase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076801 arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 protein_coding Danio_rerio
ENSG00000120318 ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 protein_coding Homo_sapiens

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