C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000120318 ARAP3 9606 - 5:141653401-141682221 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000239440 ARAP3-001 141653401-141682221 protein_coding
  ENST00000504448 ARAP3-005 141672267-141680831 protein_coding
  ENST00000508305 ARAP3-002 141653401-141682203 protein_coding
  ENST00000512390 ARAP3-003 141653408-141666744 processed_transcript
  ENST00000513878 ARAP3-004 141653791-141673160 protein_coding
  ENST00000524066 ARAP3-008 141672768-141673387 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000239440ENST00000504448ENST00000508305ENST00000512390ENST00000513878
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000239440 3.334±0.00 2.065±0.00 N/A N/A 2.267±0.00 2.703±0.00 1.642±1.46 2.224±0.00 N/A 4.025±0.00 2.380±0.83 1.758±0.62 0.499±0.00
ENST00000504448 N/A N/A N/A 0.109±0.00 N/A 0.533±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000508305 N/A 1.027±0.00 N/A N/A N/A N/A 1.700±0.00 N/A 0.500±0.00 N/A N/A N/A N/A
ENST00000512390 N/A 1.793±0.00 0.296±0.00 0.103±0.00 1.794±0.00 2.140±0.00 N/A N/A 0.250±0.02 N/A 2.203±1.15 2.796±0.91 0.365±0.00
ENST00000513878 3.121±0.00 N/A N/A N/A 2.046±0.00 N/A N/A N/A N/A 3.159±0.00 2.758±0.00 N/A 0.908±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002P1 CIL_0002P1_0001 CGP 5:141639302-141682221
CIL_0006QH CIL_0006QH_0001 CGP 5:141653401-141879246

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0005100 ISS Rho GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005547 IDA phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005622 IEA intracellular
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0007010 TAS cytoskeleton organization
GO:0007165 IEA signal transduction
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008060 ISS:IEA ARF GTPase activator activity
GO:0008270 IEA zinc ion binding
GO:0008360 ISS regulation of cell shape
GO:0016192 TAS vesicle-mediated transport
GO:0030027 ISS lamellipodium
GO:0030336 ISS negative regulation of cell migration
GO:0032312 IEA regulation of ARF GTPase activity
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035021 IEA negative regulation of Rac protein signal transduction
GO:0035024 ISS negative regulation of Rho protein signal transduction
GO:0043325 IDA phosphatidylinositol-3,4-bisphosphate binding
GO:0043547 IEA positive regulation of GTPase activity
GO:0051056 TAS regulation of small GTPase mediated signal transduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076801 arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 protein_coding Danio_rerio
ENSMUSG00000024451 Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 protein_coding Mus_musculus

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