C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SMAD family member 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024515 Smad4 10090 - 18:73639009-73703780 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025393 Smad4-001 73639009-73703780 protein_coding
  ENSMUST00000114939 Smad4-002 73640001-73678231 protein_coding
  ENSMUST00000129326 Smad4-003 73658779-73675118 processed_transcript
  ENSMUST00000131339 Smad4-004 73640158-73642563 processed_transcript
  ENSMUST00000142672 Smad4-005 73640223-73662775 processed_transcript
  ENSMUST00000147315 Smad4-006 73640212-73649819 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025393ENSMUST00000114939ENSMUST00000142672
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025393 7.236±1.14 18.327±11.10 5.954±1.02 6.219±0.85 6.561±2.73 28.729±6.31 2.325±0.11 6.493±2.34 4.114±1.46 8.495±2.77 4.597±1.28 14.840±7.11 11.353±4.29 1.717±0.17
ENSMUST00000114939 8.897±1.82 11.034±0.00 N/A 8.258±2.41 8.807±0.95 8.028±0.00 5.283±1.38 5.779±1.48 2.408±0.95 13.764±2.10 N/A 13.622±5.56 7.985±3.07 4.592±1.21
ENSMUST00000142672 7.269±1.73 11.790±0.77 N/A N/A 11.540±2.88 26.915±3.21 6.849±0.69 6.683±0.20 5.048±1.21 10.173±0.73 N/A 15.478±0.00 N/A 2.215±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001B6 CIL_0001B6_0002 CGP 18:73573044-73703780

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IEA nuclear chromatin
GO:0000987 IEA core promoter proximal region sequence-specific DNA binding
GO:0000988 IEA protein binding transcription factor activity
GO:0001076 IDA RNA polymerase II transcription factor binding transcription factor activity
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0001658 IGI branching involved in ureteric bud morphogenesis
GO:0001666 IEA response to hypoxia
GO:0001701 IMP in utero embryonic development
GO:0001702 IMP gastrulation with mouth forming second
GO:0001822 IMP kidney development
GO:0003190 IGI atrioventricular valve formation
GO:0003198 IMP epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003251 IMP positive regulation of cell proliferation involved in heart valve morphogenesis
GO:0003279 IGI cardiac septum development
GO:0003360 IMP brainstem development
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005518 IPI collagen binding
GO:0005634 IDA nucleus
GO:0005667 IPI transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005813 IEA centrosome
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007179 IGI transforming growth factor beta receptor signaling pathway
GO:0007183 IEA SMAD protein complex assembly
GO:0007369 IMP gastrulation
GO:0007411 IMP axon guidance
GO:0007492 IMP endoderm development
GO:0007498 IMP mesoderm development
GO:0008283 IMP cell proliferation
GO:0008285 IGI negative regulation of cell proliferation
GO:0009952 IMP anterior/posterior pattern specification
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0010862 IMP positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014033 IMP neural crest cell differentiation
GO:0017015 IEA regulation of transforming growth factor beta receptor signaling pathway
GO:0030308 IEA negative regulation of cell growth
GO:0030509 IEA BMP signaling pathway
GO:0030511 IEA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030513 IEA positive regulation of BMP signaling pathway
GO:0030616 IEA transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
GO:0032444 IEA activin responsive factor complex
GO:0032525 IMP somite rostral/caudal axis specification
GO:0032909 IEA regulation of transforming growth factor beta2 production
GO:0035556 IEA intracellular signal transduction
GO:0036302 IGI atrioventricular canal development
GO:0042118 IMP endothelial cell activation
GO:0042127 IGI regulation of cell proliferation
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048589 IMP developmental growth
GO:0048663 IMP neuron fate commitment
GO:0048729 IMP tissue morphogenesis
GO:0048733 IMP sebaceous gland development
GO:0048859 IMP formation of anatomical boundary
GO:0051098 IDA regulation of binding
GO:0051797 IMP regulation of hair follicle development
GO:0060021 IMP palate development
GO:0060391 IMP positive regulation of SMAD protein import into nucleus
GO:0060395 IEA SMAD protein signal transduction
GO:0060548 IMP negative regulation of cell death
GO:0060956 IMP endocardial cell differentiation
GO:0070411 IEA I-SMAD binding
GO:0070412 IEA R-SMAD binding
GO:0071141 IEA SMAD protein complex
GO:0071559 IEA response to transforming growth factor beta
GO:0072133 IMP metanephric mesenchyme morphogenesis
GO:0072134 IMP nephrogenic mesenchyme morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000086530 SMAD family member 4 protein_coding Danio_rerio
ENSG00000141646 SMAD4 SMAD family member 4 protein_coding Homo_sapiens

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