C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SMAD family member 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000025393 Smad4-001 ENSMUSG00000024515 10090 - 18:73639009-73703780 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025393
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025393 7.236±1.14 18.327±11.10 5.954±1.02 6.219±0.85 6.561±2.73 28.729±6.31 2.325±0.11 6.493±2.34 4.114±1.46 8.495±2.77 4.597±1.28 14.840±7.11 11.353±4.29 1.717±0.17

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001B6 CIL_0001B6_0002 CGP 18:73573044-73703780

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000790 IEA nuclear chromatin
GO:0000987 IEA core promoter proximal region sequence-specific DNA binding
GO:0000988 IEA protein binding transcription factor activity
GO:0001076 IDA RNA polymerase II transcription factor binding transcription factor activity
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0001658 IGI branching involved in ureteric bud morphogenesis
GO:0001666 IEA response to hypoxia
GO:0001701 IMP in utero embryonic development
GO:0001702 IMP gastrulation with mouth forming second
GO:0001822 IMP kidney development
GO:0003190 IGI atrioventricular valve formation
GO:0003198 IMP epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003251 IMP positive regulation of cell proliferation involved in heart valve morphogenesis
GO:0003279 IGI cardiac septum development
GO:0003360 IMP brainstem development
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005518 IPI collagen binding
GO:0005634 IDA nucleus
GO:0005667 IPI transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005813 IEA centrosome
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007179 IGI transforming growth factor beta receptor signaling pathway
GO:0007183 IEA SMAD protein complex assembly
GO:0007369 IMP gastrulation
GO:0007411 IMP axon guidance
GO:0007492 IMP endoderm development
GO:0007498 IMP mesoderm development
GO:0008283 IMP cell proliferation
GO:0008285 IGI negative regulation of cell proliferation
GO:0009952 IMP anterior/posterior pattern specification
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0010862 IMP positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014033 IMP neural crest cell differentiation
GO:0017015 IEA regulation of transforming growth factor beta receptor signaling pathway
GO:0030308 IEA negative regulation of cell growth
GO:0030509 IEA BMP signaling pathway
GO:0030511 IEA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030513 IEA positive regulation of BMP signaling pathway
GO:0030616 IEA transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
GO:0032444 IEA activin responsive factor complex
GO:0032525 IMP somite rostral/caudal axis specification
GO:0032909 IEA regulation of transforming growth factor beta2 production
GO:0035556 IEA intracellular signal transduction
GO:0036302 IGI atrioventricular canal development
GO:0042118 IMP endothelial cell activation
GO:0042127 IGI regulation of cell proliferation
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048589 IMP developmental growth
GO:0048663 IMP neuron fate commitment
GO:0048729 IMP tissue morphogenesis
GO:0048733 IMP sebaceous gland development
GO:0048859 IMP formation of anatomical boundary
GO:0051098 IDA regulation of binding
GO:0051797 IMP regulation of hair follicle development
GO:0060021 IMP palate development
GO:0060391 IMP positive regulation of SMAD protein import into nucleus
GO:0060395 IEA SMAD protein signal transduction
GO:0060548 IMP negative regulation of cell death
GO:0060956 IMP endocardial cell differentiation
GO:0070411 IEA I-SMAD binding
GO:0070412 IEA R-SMAD binding
GO:0071141 IEA SMAD protein complex
GO:0071559 IEA response to transforming growth factor beta
GO:0072133 IMP metanephric mesenchyme morphogenesis
GO:0072134 IMP nephrogenic mesenchyme morphogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000342988 SMAD4-201 protein_coding Homo_sapiens 0 2556
ENST00000398417 SMAD4-001 protein_coding Homo_sapiens 0 2551
ENST00000588256 RP11-729L2.2-002 processed_transcript Homo_sapiens 0 189
ENST00000588745 SMAD4-004 protein_coding Homo_sapiens 0 913
ENST00000588860 SMAD4-016 protein_coding Homo_sapiens 0 676
ENST00000589076 SMAD4-006 protein_coding Homo_sapiens 0 505
ENST00000589706 SMAD4-011 retained_intron Homo_sapiens 0 507
ENST00000589941 SMAD4-010 protein_coding Homo_sapiens 0 649
ENST00000590061 SMAD4-007 protein_coding Homo_sapiens 0 701
ENST00000590499 SMAD4-012 retained_intron Homo_sapiens 0 425
ENST00000590722 RP11-729L2.2-001 nonsense_mediated_decay Homo_sapiens 0 791
ENST00000591126 SMAD4-002 retained_intron Homo_sapiens 0 1770
ENST00000591914 SMAD4-008 protein_coding Homo_sapiens 0 795
ENST00000592186 SMAD4-005 nonsense_mediated_decay Homo_sapiens 0 1406
ENST00000592911 SMAD4-009 processed_transcript Homo_sapiens 0 586
ENST00000611848 SMAD4-017 nonsense_mediated_decay Homo_sapiens 0 952

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