C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: low density lipoprotein receptor-related protein 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024913 Lrp5 10090 - 19:3584828-3686564 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025856 Lrp5-001 3584828-3686556 protein_coding
  ENSMUST00000176867 Lrp5-003 3621671-3686564 protein_coding
  ENSMUST00000177294 Lrp5-004 3584836-3615792 nonsense_mediated_decay
  ENSMUST00000177330 Lrp5-002 3584831-3686561 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025856ENSMUST00000177294ENSMUST00000177330
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025856 7.786±4.78 29.319±7.90 2.797±0.81 0.939±0.31 7.761±3.34 11.137±4.37 4.666±1.73 6.276±2.46 6.299±3.21 20.534±5.51 4.222±0.37 13.337±5.70 17.055±12.26 N/A
ENSMUST00000177294 5.230±0.96 N/A 1.698±0.00 0.813±0.53 5.237±0.48 5.241±1.80 3.892±0.28 3.465±0.19 1.762±0.40 8.278±0.15 1.235±0.00 6.906±1.00 N/A 3.744±0.08
ENSMUST00000177330 N/A N/A 0.366±0.10 N/A N/A N/A N/A N/A 0.393±0.01 N/A N/A 1.132±0.43 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001P1 CIL_0001P1_0002 CGP 19:3454933-3686564

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001702 IGI gastrulation with mouth forming second
GO:0001944 IMP vasculature development
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0002076 IMP osteoblast development
GO:0005515 IPI protein binding
GO:0005739 IDA mitochondrion
GO:0005783 IEA endoplasmic reticulum
GO:0005886 IBA plasma membrane
GO:0006007 IEA glucose catabolic process
GO:0006897 IEA endocytosis
GO:0008203 IMP cholesterol metabolic process
GO:0008217 IEA regulation of blood pressure
GO:0008284 IEA positive regulation of cell proliferation
GO:0009952 IGI anterior/posterior pattern specification
GO:0015026 IBA coreceptor activity
GO:0016021 IEA integral component of membrane
GO:0016055 IDA Wnt signaling pathway
GO:0017147 IPI Wnt-protein binding
GO:0030278 IBA regulation of ossification
GO:0033690 IMP positive regulation of osteoblast proliferation
GO:0035019 IMP somatic stem cell maintenance
GO:0035108 IGI limb morphogenesis
GO:0035426 IDA extracellular matrix-cell signaling
GO:0042074 IGI cell migration involved in gastrulation
GO:0042632 IBA cholesterol homeostasis
GO:0042733 IGI embryonic digit morphogenesis
GO:0042813 IDA Wnt-activated receptor activity
GO:0042981 IMP regulation of apoptotic process
GO:0043235 IBA receptor complex
GO:0043434 IEA response to peptide hormone
GO:0044332 IBA Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045598 IBA regulation of fat cell differentiation
GO:0045600 IEA positive regulation of fat cell differentiation
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045840 IEA positive regulation of mitosis
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IBA positive regulation of transcription from RNA polymerase II promoter
GO:0046849 IMP bone remodeling
GO:0046850 IMP regulation of bone remodeling
GO:0048539 IBA bone marrow development
GO:0048596 IBA embryonic camera-type eye morphogenesis
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060033 IMP anatomical structure regression
GO:0060042 IEA retina morphogenesis in camera-type eye
GO:0060059 IBA embryonic retina morphogenesis in camera-type eye
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060348 IMP bone development
GO:0060349 IBA bone morphogenesis
GO:0060444 IMP branching involved in mammary gland duct morphogenesis
GO:0060603 IGI mammary gland duct morphogenesis
GO:0060612 IBA adipose tissue development
GO:0060764 IMP cell-cell signaling involved in mammary gland development
GO:0060828 IEA regulation of canonical Wnt signaling pathway
GO:0061178 IMP regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061299 IMP retina vasculature morphogenesis in camera-type eye
GO:0061304 IBA retinal blood vessel morphogenesis
GO:0071901 IEA negative regulation of protein serine/threonine kinase activity
GO:1902262 IMP apoptotic process involved in patterning of blood vessels

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006921 lrp5 low density lipoprotein receptor-related protein 5 protein_coding Danio_rerio
ENSG00000162337 LRP5 low density lipoprotein receptor-related protein 5 protein_coding Homo_sapiens

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