C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: low density lipoprotein receptor-related protein 5
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000025856 Lrp5-001 ENSMUSG00000024913 10090 - 19:3584828-3686556 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000025856
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000025856 7.786±4.78 29.319±7.90 2.797±0.81 0.939±0.31 7.761±3.34 11.137±4.37 4.666±1.73 6.276±2.46 6.299±3.21 20.534±5.51 4.222±0.37 13.337±5.70 17.055±12.26

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001P1 CIL_0001P1_0002 CGP 19:3454933-3686564

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001702 IGI gastrulation with mouth forming second
GO:0001944 IMP vasculature development
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0002076 IMP osteoblast development
GO:0005515 IPI protein binding
GO:0005739 IDA mitochondrion
GO:0005783 IEA endoplasmic reticulum
GO:0005886 IBA plasma membrane
GO:0006007 IEA glucose catabolic process
GO:0006897 IEA endocytosis
GO:0008203 IMP cholesterol metabolic process
GO:0008217 IEA regulation of blood pressure
GO:0008284 IEA positive regulation of cell proliferation
GO:0009952 IGI anterior/posterior pattern specification
GO:0015026 IBA coreceptor activity
GO:0016021 IEA integral component of membrane
GO:0016055 IDA Wnt signaling pathway
GO:0017147 IPI Wnt-protein binding
GO:0030278 IBA regulation of ossification
GO:0033690 IMP positive regulation of osteoblast proliferation
GO:0035019 IMP somatic stem cell maintenance
GO:0035108 IGI limb morphogenesis
GO:0035426 IDA extracellular matrix-cell signaling
GO:0042074 IGI cell migration involved in gastrulation
GO:0042632 IBA cholesterol homeostasis
GO:0042733 IGI embryonic digit morphogenesis
GO:0042813 IDA Wnt-activated receptor activity
GO:0042981 IMP regulation of apoptotic process
GO:0043235 IBA receptor complex
GO:0043434 IEA response to peptide hormone
GO:0044332 IBA Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045598 IBA regulation of fat cell differentiation
GO:0045600 IEA positive regulation of fat cell differentiation
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045840 IEA positive regulation of mitosis
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IBA positive regulation of transcription from RNA polymerase II promoter
GO:0046849 IMP bone remodeling
GO:0046850 IMP regulation of bone remodeling
GO:0048539 IBA bone marrow development
GO:0048596 IBA embryonic camera-type eye morphogenesis
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060033 IMP anatomical structure regression
GO:0060042 IEA retina morphogenesis in camera-type eye
GO:0060059 IBA embryonic retina morphogenesis in camera-type eye
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060348 IMP bone development
GO:0060349 IBA bone morphogenesis
GO:0060444 IMP branching involved in mammary gland duct morphogenesis
GO:0060603 IGI mammary gland duct morphogenesis
GO:0060612 IBA adipose tissue development
GO:0060764 IMP cell-cell signaling involved in mammary gland development
GO:0060828 IEA regulation of canonical Wnt signaling pathway
GO:0061178 IMP regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061299 IMP retina vasculature morphogenesis in camera-type eye
GO:0061304 IBA retinal blood vessel morphogenesis
GO:0071901 IEA negative regulation of protein serine/threonine kinase activity
GO:1902262 IMP apoptotic process involved in patterning of blood vessels

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000294304 LRP5-001 protein_coding Homo_sapiens 0 5781
ENST00000402785 LRP5L-001 protein_coding Homo_sapiens 0 896
ENST00000402859 LRP5L-201 protein_coding Homo_sapiens 0 913
ENST00000444995 LRP5L-005 protein_coding Homo_sapiens 0 634
ENST00000467672 LRP5L-006 retained_intron Homo_sapiens 0 915
ENST00000468442 LRP5L-002 protein_coding Homo_sapiens 0 331
ENST00000474163 LRP5L-004 nonsense_mediated_decay Homo_sapiens 0 427
ENST00000528714 LRP5-003 processed_transcript Homo_sapiens 0 359
ENST00000529993 LRP5-002 nonsense_mediated_decay Homo_sapiens 0 3657
ENST00000610821 LRP5L-202 protein_coding Homo_sapiens 0 915

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