C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: multiple endocrine neoplasia 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024947 Men1 10090 + 19:6334979-6340891 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000056391 Men1-003 6335039-6340889 protein_coding
  ENSMUST00000078137 Men1-004 6335111-6340889 protein_coding
  ENSMUST00000079327 Men1-002 6335013-6340889 protein_coding
  ENSMUST00000113500 Men1-007 6335047-6340783 protein_coding
  ENSMUST00000113501 Men1-005 6335039-6340889 protein_coding
  ENSMUST00000113502 Men1-201 6334979-6340880 protein_coding
  ENSMUST00000113503 Men1-008 6335461-6340172 protein_coding
  ENSMUST00000113504 Men1-001 6334979-6340891 protein_coding
  ENSMUST00000156154 Men1-006 6335046-6340891 retained_intron
  ENSMUST00000166909 Men1-009 6335064-6340463 protein_coding
  ENSMUST00000170132 Men1-011 6336910-6338408 protein_coding
  ENSMUST00000170292 Men1-010 6339847-6340812 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000056391ENSMUST00000078137ENSMUST00000079327ENSMUST00000113500ENSMUST00000113501ENSMUST00000113502ENSMUST00000113504ENSMUST00000156154ENSMUST00000170132
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000056391 2.650±0.76 3.177±0.25 2.114±0.52 8.097±1.57 N/A 2.397±0.26 0.849±0.00 2.425±0.23 2.168±0.98 2.478±0.00 0.924±0.62 4.476±0.43 5.886±1.58 1.496±0.01
ENSMUST00000078137 N/A N/A N/A 7.307±0.00 N/A N/A N/A N/A N/A N/A 0.512±0.00 3.857±1.42 8.504±0.60 0.638±0.00
ENSMUST00000079327 9.495±2.07 8.474±2.24 7.410±1.17 32.079±10.12 9.188±1.39 7.195±1.08 3.002±1.28 10.277±0.94 6.296±1.54 9.503±1.50 0.960±0.58 17.844±5.05 8.680±3.40 5.348±0.76
ENSMUST00000113500 N/A N/A N/A 11.338±0.00 N/A N/A N/A N/A N/A N/A 0.289±0.00 6.653±5.12 8.991±1.25 1.255±0.00
ENSMUST00000113501 N/A N/A N/A N/A 2.519±0.00 N/A N/A N/A N/A N/A N/A 5.828±2.87 N/A N/A
ENSMUST00000113502 5.340±0.67 11.952±0.63 3.172±0.03 5.152±0.44 8.393±2.09 8.562±1.74 1.746±0.44 10.930±0.88 3.234±1.03 6.673±1.84 1.003±0.53 7.475±1.77 5.302±1.78 4.259±0.96
ENSMUST00000113504 N/A 10.112±1.24 3.162±0.00 N/A N/A N/A N/A 6.530±1.82 1.560±0.00 N/A 1.578±0.00 N/A 4.482±0.00 N/A
ENSMUST00000156154 3.248±0.69 4.720±0.54 2.197±0.31 4.113±1.29 4.373±1.69 3.704±0.51 1.581±0.24 3.327±0.54 1.912±0.57 4.745±0.26 0.313±0.08 8.481±2.99 N/A 1.704±0.02
ENSMUST00000170132 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 23.010±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001YX CIL_0001YX_0002 CGP 19:6334979-6355615

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000165 IEA MAPK cascade
GO:0000400 IEA four-way junction DNA binding
GO:0000403 IEA Y-form DNA binding
GO:0000785 IEA chromatin
GO:0001503 IMP ossification
GO:0001776 IMP leukocyte homeostasis
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0002051 IGI osteoblast fate commitment
GO:0002076 IGI osteoblast development
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003690 IEA double-stranded DNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0006338 IMP chromatin remodeling
GO:0006351 IEA transcription, DNA-templated
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007050 IMP cell cycle arrest
GO:0007420 IEA brain development
GO:0008285 IMP negative regulation of cell proliferation
GO:0009411 IEA response to UV
GO:0010332 IEA response to gamma radiation
GO:0016363 IEA nuclear matrix
GO:0016571 IDA histone methylation
GO:0018024 IEA histone-lysine N-methyltransferase activity
GO:0030097 IMP hemopoiesis
GO:0030511 IEA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030674 IEA protein binding, bridging
GO:0031062 IMP positive regulation of histone methylation
GO:0032092 IEA positive regulation of protein binding
GO:0032154 IEA cleavage furrow
GO:0032925 IEA regulation of activin receptor signaling pathway
GO:0034968 IEA histone lysine methylation
GO:0035097 ISO histone methyltransferase complex
GO:0043065 IDA positive regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045597 IMP positive regulation of cell differentiation
GO:0045668 IDA negative regulation of osteoblast differentiation
GO:0045669 IGI positive regulation of osteoblast differentiation
GO:0045736 IEA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786 IEA negative regulation of cell cycle
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046329 IEA negative regulation of JNK cascade
GO:0046621 IDA negative regulation of organ growth
GO:0047485 IEA protein N-terminus binding
GO:0048704 IMP embryonic skeletal system morphogenesis
GO:0051781 IMP positive regulation of cell division
GO:0051974 IEA negative regulation of telomerase activity
GO:0060021 IMP palate development
GO:0060135 IDA maternal process involved in female pregnancy
GO:0070412 IEA R-SMAD binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058021 men1 multiple endocrine neoplasia type 1 protein_coding Danio_rerio
ENSDARG00000089456 men1 multiple endocrine neoplasia type 1 protein_coding Danio_rerio
ENSG00000133895 MEN1 multiple endocrine neoplasia I protein_coding Homo_sapiens

Loading