C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024948 Map4k2 10090 + 19:6341135-6355615 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025897 Map4k2-001 6341160-6355615 protein_coding
  ENSMUST00000123468 Map4k2-009 6341471-6343521 retained_intron
  ENSMUST00000124333 Map4k2-020 6341270-6343523 retained_intron
  ENSMUST00000124556 Map4k2-002 6341208-6355301 nonsense_mediated_decay
  ENSMUST00000126841 Map4k2-014 6345350-6346293 retained_intron
  ENSMUST00000127809 Map4k2-021 6341418-6343858 processed_transcript
  ENSMUST00000128170 Map4k2-022 6346692-6353838 nonsense_mediated_decay
  ENSMUST00000130382 Map4k2-018 6341224-6345742 protein_coding
  ENSMUST00000133696 Map4k2-003 6341135-6355612 retained_intron
  ENSMUST00000134307 Map4k2-012 6342537-6342845 retained_intron
  ENSMUST00000137095 Map4k2-005 6346549-6353840 retained_intron
  ENSMUST00000140098 Map4k2-016 6350909-6351580 retained_intron
  ENSMUST00000142496 Map4k2-019 6341250-6353527 nonsense_mediated_decay
  ENSMUST00000142862 Map4k2-017 6352775-6353633 processed_transcript
  ENSMUST00000148410 Map4k2-011 6341216-6342874 retained_intron
  ENSMUST00000149624 Map4k2-010 6341191-6341996 processed_transcript
  ENSMUST00000152259 Map4k2-004 6341779-6351887 retained_intron
  ENSMUST00000152349 Map4k2-007 6341155-6342656 nonsense_mediated_decay
  ENSMUST00000152912 Map4k2-013 6343516-6344647 retained_intron
  ENSMUST00000154900 Map4k2-015 6346669-6351659 processed_transcript
  ENSMUST00000155569 Map4k2-008 6341449-6343521 processed_transcript
  ENSMUST00000155655 Map4k2-006 6352620-6355442 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryENSMUST00000025897ENSMUST00000124556ENSMUST00000142496ENSMUST00000155655
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary
ENSMUST00000025897 11.562±2.09 21.380±0.32 16.907±2.19 14.243±4.38 37.001±13.23 11.788±1.20 9.768±2.78 11.516±4.08 7.394±2.78 54.443±11.00 3.838±0.89 22.220±5.53
ENSMUST00000124556 10.995±0.87 22.605±3.29 N/A N/A 19.326±5.29 N/A 8.736±0.85 9.472±1.77 3.939±0.03 32.791±3.23 N/A N/A
ENSMUST00000142496 N/A N/A N/A N/A 29.954±5.67 N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000155655 N/A N/A N/A N/A 13.866±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001YX CIL_0001YX_0002 CGP 19:6334979-6355615

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005083 IEA small GTPase regulator activity
GO:0005515 IEA protein binding
GO:0005524 ISS ATP binding
GO:0005794 IEA Golgi apparatus
GO:0005886 IEA plasma membrane
GO:0006468 ISS protein phosphorylation
GO:0006903 IDA vesicle targeting
GO:0007257 IEA activation of JUN kinase activity
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0035556 ISS intracellular signal transduction
GO:0045087 IEA innate immune response
GO:0046330 IEA positive regulation of JNK cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001234 map4k2l mitogen-activated protein kinase kinase kinase kinase 2-like protein_coding Danio_rerio
ENSDARG00000033444 MAP4K2 (2 of 3) mitogen-activated protein kinase kinase kinase kinase 2 protein_coding Danio_rerio
ENSDARG00000088706 map4k2l mitogen-activated protein kinase kinase kinase kinase 2-like protein_coding Danio_rerio
ENSG00000168067 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 protein_coding Homo_sapiens

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