C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168067 MAP4K2 9606 - 11:64788818-64803241 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000294066 MAP4K2-001 64789137-64803241 protein_coding
  ENST00000377350 MAP4K2-002 64789137-64803241 protein_coding
  ENST00000424945 MAP4K2-005 64789137-64796498 nonsense_mediated_decay
  ENST00000433890 MAP4K2-014 64789537-64803149 nonsense_mediated_decay
  ENST00000435926 MAP4K2-012 64788818-64803162 nonsense_mediated_decay
  ENST00000439069 MAP4K2-006 64799421-64803175 protein_coding
  ENST00000444560 MAP4K2-013 64801710-64803227 nonsense_mediated_decay
  ENST00000467689 MAP4K2-009 64796971-64799634 retained_intron
  ENST00000468062 MAP4K2-010 64800348-64803129 processed_transcript
  ENST00000470088 MAP4K2-004 64789137-64797343 retained_intron
  ENST00000482314 MAP4K2-007 64800336-64803010 processed_transcript
  ENST00000489952 MAP4K2-008 64789889-64799659 retained_intron
  ENST00000493428 MAP4K2-011 64800182-64801813 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000294066ENST00000377350ENST00000424945ENST00000433890ENST00000435926ENST00000439069ENST00000444560ENST00000468062ENST00000470088ENST00000489952ENST00000493428
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000294066 1.721±0.00 6.186±0.00 N/A 2.059±0.28 2.212±0.00 0.377±0.00 1.361±0.00 2.378±0.00 N/A 4.318±3.96 1.296±0.00 3.229±0.06 6.207±3.43 3.320±0.00
ENST00000377350 N/A N/A N/A N/A N/A 0.470±0.00 0.275±0.00 N/A 0.658±0.37 N/A N/A 0.566±0.00 N/A N/A
ENST00000424945 2.856±0.00 8.020±0.00 N/A N/A 2.346±0.00 0.990±0.50 0.705±0.00 2.497±0.00 0.437±0.08 N/A N/A 4.975±1.58 7.309±0.61 6.259±0.00
ENST00000433890 1.204±0.00 N/A 0.145±0.00 N/A 0.872±0.00 0.545±0.00 N/A N/A N/A N/A 0.394±0.13 1.801±0.00 N/A N/A
ENST00000435926 N/A N/A N/A N/A N/A 0.286±0.00 N/A N/A N/A N/A N/A 1.233±0.00 1.954±0.00 0.785±0.00
ENST00000439069 N/A N/A N/A 1.516±0.00 N/A N/A N/A 0.551±0.00 N/A N/A N/A 2.174±0.00 N/A N/A
ENST00000444560 N/A N/A 0.561±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000468062 N/A N/A N/A N/A N/A N/A N/A N/A 1.204±0.00 1.014±0.00 N/A N/A N/A N/A
ENST00000470088 N/A 4.349±0.00 N/A 2.492±0.00 N/A N/A N/A 0.689±0.00 0.554±0.00 2.554±2.13 N/A 1.659±0.00 N/A 3.393±0.00
ENST00000489952 1.179±0.00 N/A N/A N/A 0.656±0.00 0.869±0.22 N/A N/A N/A N/A N/A 5.084±0.00 6.641±0.00 5.620±0.00
ENST00000493428 N/A N/A 0.683±0.00 N/A N/A 1.673±0.00 N/A N/A N/A N/A N/A 5.758±0.00 8.858±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005JE CIL_0005JE_0002 CGP 11:64788818-64811294

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005083 IEA small GTPase regulator activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005886 IEA plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0006903 IEA vesicle targeting
GO:0006955 TAS immune response
GO:0007254 TAS JNK cascade
GO:0007257 IDA activation of JUN kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0031435 IPI mitogen-activated protein kinase kinase kinase binding
GO:0035556 IDA intracellular signal transduction
GO:0045087 IEA innate immune response
GO:0046330 IDA positive regulation of JNK cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001234 map4k2l mitogen-activated protein kinase kinase kinase kinase 2-like protein_coding Danio_rerio
ENSDARG00000033444 MAP4K2 (2 of 3) mitogen-activated protein kinase kinase kinase kinase 2 protein_coding Danio_rerio
ENSDARG00000088706 map4k2l mitogen-activated protein kinase kinase kinase kinase 2-like protein_coding Danio_rerio
ENSMUSG00000024948 Map4k2 mitogen-activated protein kinase kinase kinase kinase 2 protein_coding Mus_musculus

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