C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025422 Agap2 10090 + 10:127078907-127093169 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000039259 Agap2-201 127078907-127093169 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000039259
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000039259 4.486±3.89 2.660±0.39 1.578±0.15 101.955±25.13 5.741±4.13 1.823±0.18 0.841±0.11 0.339±0.10 0.318±0.23 0.942±0.19 0.823±0.08 5.164±2.04 0.079±0.03

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005525 IEA GTP binding
GO:0005634 IEA nucleus
GO:0005730 IEA nucleolus
GO:0005739 IEA mitochondrion
GO:0007264 IEA small GTPase mediated signal transduction
GO:0008060 IEA ARF GTPase activator activity
GO:0008270 IEA zinc ion binding
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019901 IEA protein kinase binding
GO:0030295 IEA protein kinase activator activity
GO:0032312 IEA regulation of ARF GTPase activity
GO:0033601 IGI positive regulation of mammary gland epithelial cell proliferation
GO:0043066 IMP negative regulation of apoptotic process
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043547 IEA positive regulation of GTPase activity
GO:0045860 IEA positive regulation of protein kinase activity
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046427 IMP positive regulation of JAK-STAT cascade
GO:0060749 IMP mammary gland alveolus development
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061117 agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 protein_coding Danio_rerio
ENSG00000135439 AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 protein_coding Homo_sapiens

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