C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: telomeric repeat binding factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025925 Terf1 10090 + 1:15805646-15844052 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027057 Terf1-002 15805664-15843470 protein_coding
  ENSMUST00000186565 Terf1-004 15805657-15822015 processed_transcript
  ENSMUST00000188371 Terf1-001 15805646-15844052 protein_coding
  ENSMUST00000188684 Terf1-003 15807641-15822103 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027057ENSMUST00000186565ENSMUST00000188371ENSMUST00000188684
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027057 0.533±0.11 0.949±0.41 2.789±0.01 4.645±3.61 0.319±0.14 0.466±0.08 0.334±0.00 0.959±0.28 4.762±4.21 0.958±0.19 0.855±0.14 10.585±10.22 17.403±16.23 12.774±20.11
ENSMUST00000186565 2.396±0.99 3.272±1.12 1.437±0.00 1.593±0.10 3.021±2.30 3.903±0.88 0.941±0.24 2.258±0.56 3.129±2.15 5.192±1.01 0.442±0.18 5.516±2.22 4.437±0.02 4.757±0.47
ENSMUST00000188371 N/A N/A 0.645±0.01 N/A 0.598±0.00 0.409±0.11 0.206±0.00 0.292±0.00 1.190±0.43 0.936±0.28 0.390±0.05 0.850±0.22 1.333±0.39 N/A
ENSMUST00000188684 N/A N/A N/A 0.227±0.00 0.083±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003GB CIL_0003GB_0002 CGP 1:15287254-15844052
CIL_000132 CIL_000132_0002 CGP 1:15805646-15892722

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 IEA G2/M transition of mitotic cell cycle
GO:0000723 IBA telomere maintenance
GO:0000783 IDA nuclear telomere cap complex
GO:0000784 IDA nuclear chromosome, telomeric region
GO:0001309 IEA age-dependent telomere shortening
GO:0003682 IEA chromatin binding
GO:0003691 ISS double-stranded telomeric DNA binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005730 IEA nucleolus
GO:0005737 IEA cytoplasm
GO:0005819 IEA spindle
GO:0005856 IEA cytoskeleton
GO:0006919 IBA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007067 IEA mitotic nuclear division
GO:0007094 IEA mitotic spindle assembly checkpoint
GO:0008017 IEA microtubule binding
GO:0008156 IEA negative regulation of DNA replication
GO:0008301 IEA DNA binding, bending
GO:0010834 IEA telomere maintenance via telomere shortening
GO:0031116 IEA positive regulation of microtubule polymerization
GO:0032211 IEA negative regulation of telomere maintenance via telomerase
GO:0042162 IBA telomeric DNA binding
GO:0042493 IEA response to drug
GO:0042803 IEA protein homodimerization activity
GO:0043065 IEA positive regulation of apoptotic process
GO:0045840 IEA positive regulation of mitosis
GO:0045931 IEA positive regulation of mitotic cell cycle
GO:0046982 IEA protein heterodimerization activity
GO:0051260 IEA protein homooligomerization
GO:0051974 IEA negative regulation of telomerase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058710 terf1 telomeric repeat binding factor (NIMA-interacting) 1 protein_coding Danio_rerio
ENSG00000147601 TERF1 telomeric repeat binding factor (NIMA-interacting) 1 protein_coding Homo_sapiens

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