C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cytotoxic T-lymphocyte-associated protein 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026011 Ctla4 10090 + 1:60887000-60915832 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027164 Ctla4-001 60909025-60915832 protein_coding
  ENSMUST00000097720 Ctla4-002 60909171-60914769 protein_coding
  ENSMUST00000124816 Ctla4-004 60887000-60912716 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027164ENSMUST00000097720ENSMUST00000124816
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027164 0.043±0.03 0.109±0.04 0.065±0.01 0.023±0.00 1.526±0.71 0.118±0.07 0.118±0.03 0.058±0.03 0.004±0.00 0.175±0.07 0.091±0.03 0.036±0.00 0.046±0.03 0.031±0.00
ENSMUST00000097720 N/A N/A N/A 0.015±0.00 1.399±0.00 N/A N/A 0.076±0.04 0.100±0.00 N/A 0.088±0.00 0.220±0.10 0.076±0.05 0.161±0.00
ENSMUST00000124816 N/A N/A N/A 0.208±0.00 N/A 0.075±0.00 0.185±0.01 N/A N/A N/A 0.103±0.00 N/A N/A 0.036±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000398 CIL_000398_0002 CGP 1:60716800-60915832
CIL_00039C CIL_00039C_0002 CGP 1:60887000-61000320

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IEA protein binding
GO:0005794 IEA Golgi apparatus
GO:0006955 IEA immune response
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0009897 IDA external side of plasma membrane
GO:0030889 IEA negative regulation of B cell proliferation
GO:0042130 IEA negative regulation of T cell proliferation
GO:0043065 IEA positive regulation of apoptotic process
GO:0045334 IEA clathrin-coated endocytic vesicle
GO:0045590 IEA negative regulation of regulatory T cell differentiation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050777 IEA negative regulation of immune response
GO:0050853 IEA B cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000163599 CTLA4 cytotoxic T-lymphocyte-associated protein 4 protein_coding Homo_sapiens

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