C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: caspase 8
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000165549 Casp8-002 ENSMUSG00000026029 10090 + 1:58802502-58847008 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000165549
Transcript ID Adipose Adrenal Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000165549 1.947±1.29 0.442±0.25 6.267±0.96 0.494±0.35 2.056±0.51 0.573±0.21 1.932±0.75 2.995±1.86 2.224±1.23 0.814±0.43 4.634±4.35 2.646±0.79 0.175±0.04

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089O CIL_00089O_0002 VISTA 1:58652904-59256413

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001525 IMP angiogenesis
GO:0001841 IMP neural tube formation
GO:0004175 IDA endopeptidase activity
GO:0004197 IDA cysteine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0006915 IDA apoptotic process
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007507 IMP heart development
GO:0008233 IDA peptidase activity
GO:0008625 IMP extrinsic apoptotic signaling pathway via death domain receptors
GO:0030225 IMP macrophage differentiation
GO:0030690 IMP Noc1p-Noc2p complex
GO:0035877 IBA death effector domain binding
GO:0046982 IPI protein heterodimerization activity
GO:0048738 TAS cardiac muscle tissue development
GO:0060546 IGI negative regulation of necroptotic process
GO:0070243 IGI regulation of thymocyte apoptotic process
GO:0097153 IDA cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 IDA apoptotic signaling pathway
GO:0097191 IDA extrinsic apoptotic signaling pathway
GO:0097194 ISS execution phase of apoptosis
GO:0097284 IMP hepatocyte apoptotic process
GO:0097342 ISS ripoptosome
GO:2001233 IGI regulation of apoptotic signaling pathway
GO:2001238 IGI positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000264275 CASP8-006 protein_coding Homo_sapiens 0 540
ENST00000323492 CASP8-012 protein_coding Homo_sapiens 0 540
ENST00000339403 CASP8-007 retained_intron Homo_sapiens 0 388
ENST00000358485 CASP8-002 protein_coding Homo_sapiens 0 798
ENST00000392258 CASP8-004 protein_coding Homo_sapiens 2e-19 100
ENST00000392263 CASP8-009 protein_coding Homo_sapiens 0 538
ENST00000392266 CASP8-202 protein_coding Homo_sapiens 1e-28 132
ENST00000424461 CASP8-016 protein_coding Homo_sapiens 7e-20 100
ENST00000432109 CASP8-014 protein_coding Homo_sapiens 0 795
ENST00000447616 CASP8-010 protein_coding Homo_sapiens 2e-19 100
ENST00000450491 CASP8-020 protein_coding Homo_sapiens 5e-29 132

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