C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: optineurin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026672 Optn 10090 - 2:5020642-5064051 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027986 Optn-002 5020644-5063938 protein_coding
  ENSMUST00000114996 Optn-001 5020642-5064045 protein_coding
  ENSMUST00000125203 Optn-003 5020642-5035903 processed_transcript
  ENSMUST00000143809 Optn-005 5046157-5064051 processed_transcript
  ENSMUST00000145501 Optn-004 5021301-5037197 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027986ENSMUST00000114996ENSMUST00000125203ENSMUST00000143809ENSMUST00000145501
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027986 0.516±0.00 N/A N/A 4.918±0.00 N/A N/A 1.810±0.00 N/A 0.934±0.00 N/A 3.805±0.00 2.684±0.75 12.031±9.02 56.920±0.00
ENSMUST00000114996 3.699±1.79 10.386±1.17 3.508±0.36 3.310±2.43 2.375±0.67 6.409±1.23 5.031±1.92 1.615±0.40 5.334±2.30 2.486±0.56 21.246±2.51 1.894±1.51 14.348±7.17 22.601±2.41
ENSMUST00000125203 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.376±0.00 1.892±0.00 N/A
ENSMUST00000143809 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.779±0.00 N/A N/A
ENSMUST00000145501 N/A N/A N/A 28.160±0.00 N/A N/A N/A N/A N/A N/A N/A 11.634±11.02 99.824±0.16 207.927±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000968 CIL_000968_0002 VISTA 2:4582644-5183763

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000042 IEA protein targeting to Golgi
GO:0001920 IEA negative regulation of receptor recycling
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005768 IEA endosome
GO:0005794 IEA Golgi apparatus
GO:0005802 ISS trans-Golgi network
GO:0006914 IEA autophagy
GO:0007030 IEA Golgi organization
GO:0008022 IEA protein C-terminus binding
GO:0016236 IEA macroautophagy
GO:0017137 IEA Rab GTPase binding
GO:0031410 IEA cytoplasmic vesicle
GO:0031593 IEA polyubiquitin binding
GO:0034613 IMP cellular protein localization
GO:0043001 IEA Golgi to plasma membrane protein transport
GO:0043124 IMP negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050829 IEA defense response to Gram-negative bacterium
GO:0070530 IDA K63-linked polyubiquitin binding
GO:0090161 ISS Golgi ribbon formation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002663 optn optineurin protein_coding Danio_rerio
ENSG00000123240 OPTN optineurin protein_coding Homo_sapiens

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