C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: kynureninase (L-kynurenine hydrolase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026866 Kynu 10090 + 2:43555329-43682715 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028223 Kynu-001 43555329-43682715 protein_coding
  ENSMUST00000050511 Kynu-003 43555354-43636758 protein_coding
  ENSMUST00000112826 Kynu-002 43555342-43680216 protein_coding
  ENSMUST00000130968 Kynu-005 43599615-43606198 processed_transcript
  ENSMUST00000138540 Kynu-004 43555329-43563496 processed_transcript
  ENSMUST00000148855 Kynu-006 43670930-43681423 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028223ENSMUST00000050511ENSMUST00000112826ENSMUST00000130968ENSMUST00000138540ENSMUST00000148855
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028223 0.059±0.05 0.073±0.02 0.050±0.03 0.036±0.02 0.979±0.35 0.255±0.21 0.081±0.04 5.504±2.56 23.625±23.12 0.518±0.13 0.095±0.00 0.095±0.05 1.075±0.90 0.015±0.00
ENSMUST00000050511 N/A N/A N/A 0.008±0.00 N/A N/A 0.012±0.00 N/A N/A 0.093±0.01 N/A N/A N/A N/A
ENSMUST00000112826 0.107±0.08 N/A 0.051±0.02 0.036±0.00 N/A N/A N/A N/A 0.939±0.26 0.384±0.00 0.092±0.00 0.080±0.00 1.655±0.00 N/A
ENSMUST00000130968 N/A 0.100±0.02 N/A N/A N/A 0.134±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000138540 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.316±0.00 N/A N/A
ENSMUST00000148855 N/A N/A N/A N/A N/A 0.174±0.00 N/A N/A N/A N/A 0.034±0.00 N/A 0.036±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003NW CIL_0003NW_0002 CGP 2:40595248-43682715
CIL_0008RY CIL_0008RY_0002 VISTA 2:43481987-44083031
CIL_0006M7 CIL_0006M7_0002 CGP 2:43555329-44395953

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005739 IDA mitochondrion
GO:0005829 IEA cytosol
GO:0006569 IEA tryptophan catabolic process
GO:0009435 IEA NAD biosynthetic process
GO:0019441 IEA tryptophan catabolic process to kynurenine
GO:0019442 IEA tryptophan catabolic process to acetyl-CoA
GO:0019805 IEA quinolinate biosynthetic process
GO:0030170 IEA pyridoxal phosphate binding
GO:0030429 IEA kynureninase activity
GO:0034341 IEA response to interferon-gamma
GO:0034354 IEA 'de novo' NAD biosynthetic process from tryptophan
GO:0034516 IEA response to vitamin B6
GO:0042803 IEA protein homodimerization activity
GO:0043420 IEA anthranilate metabolic process
GO:0097053 IEA L-kynurenine catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000028345 KYNU (1 of 2) kynureninase protein_coding Danio_rerio
ENSDARG00000096343 KYNU (2 of 2) kynureninase protein_coding Danio_rerio
ENSG00000115919 KYNU kynureninase protein_coding Homo_sapiens

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