C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cholinergic receptor, nicotinic, alpha polypeptide 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027577 Chrna4 10090 - 2:181018380-181043546 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000067120 Chrna4-001 181022311-181039305 protein_coding
  ENSMUST00000108851 Chrna4-002 181018380-181039187 protein_coding
  ENSMUST00000124400 Chrna4-003 181034024-181043546 protein_coding
  ENSMUST00000135766 Chrna4-004 181029425-181039225 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000067120ENSMUST00000108851ENSMUST00000135766
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000067120 0.106±0.02 2.281±0.41 0.014±0.00 7.146±2.15 0.033±0.01 0.036±0.02 0.014±0.00 10.623±3.25 0.686±0.61 0.012±0.00 0.025±0.01 0.900±0.61 0.909±0.65 0.198±0.12
ENSMUST00000108851 N/A 1.634±0.42 0.020±0.00 2.231±0.00 0.032±0.04 0.039±0.02 N/A N/A 0.404±0.20 N/A 0.026±0.01 0.693±0.22 N/A 0.174±0.05
ENSMUST00000135766 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.053±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00010A CIL_00010A_0002 CGP 2:180986535-181043546
CIL_0000X3 CIL_0000X3_0002 CGP 2:181018380-181135291

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001508 IMP action potential
GO:0001666 IEA response to hypoxia
GO:0004889 TAS acetylcholine-activated cation-selective channel activity
GO:0005216 IDA ion channel activity
GO:0005515 IPI protein binding
GO:0005886 IDA plasma membrane
GO:0005892 IDA acetylcholine-gated channel complex
GO:0006281 IEA DNA repair
GO:0006816 IGI calcium ion transport
GO:0006979 IEA response to oxidative stress
GO:0007165 IEA signal transduction
GO:0007271 IMP synaptic transmission, cholinergic
GO:0007585 IMP respiratory gaseous exchange
GO:0007626 IMP locomotory behavior
GO:0009897 IDA external side of plasma membrane
GO:0014059 IMP regulation of dopamine secretion
GO:0015464 IEA acetylcholine receptor activity
GO:0016020 IDA membrane
GO:0019233 IMP sensory perception of pain
GO:0030054 IEA cell junction
GO:0034220 IDA ion transmembrane transport
GO:0035094 IMP response to nicotine
GO:0035095 IMP behavioral response to nicotine
GO:0035640 IMP exploration behavior
GO:0042113 IMP B cell activation
GO:0042391 IGI regulation of membrane potential
GO:0045211 IEA postsynaptic membrane
GO:0050877 IMP neurological system process
GO:0050890 IEA cognition
GO:0051899 IMP membrane depolarization
GO:0060080 IMP regulation of inhibitory postsynaptic membrane potential
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058393 chrna4b cholinergic receptor, nicotinic, alpha 4b protein_coding Danio_rerio
ENSDARG00000070724 chrna4b cholinergic receptor, nicotinic, alpha 4b protein_coding Danio_rerio
ENSDARG00000087071 CHRNA4 (3 of 3) cholinergic receptor, nicotinic, alpha 4 (neuronal) protein_coding Danio_rerio
ENSG00000101204 CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) protein_coding Homo_sapiens

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