C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cholinergic receptor, nicotinic, alpha 4 (neuronal)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101204 CHRNA4 9606 - 20:63343310-63378401 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000370263 CHRNA4-001 63344068-63361387 protein_coding
  ENST00000463705 CHRNA4-002 63344069-63377993 processed_transcript
  ENST00000467563 CHRNA4-004 63346594-63361304 processed_transcript
  ENST00000475033 CHRNA4-003 63370753-63378137 processed_transcript
  ENST00000480012 CHRNA4-006 63374421-63378401 processed_transcript
  ENST00000498043 CHRNA4-007 63346594-63359699 nonsense_mediated_decay
  ENST00000615287 CHRNA4-201 63343310-63361396 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000370263ENST00000467563ENST00000498043ENST00000615287
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000370263 N/A 0.349±0.00 4.499±0.00 N/A 0.052±0.00 0.038±0.00 0.219±0.10 4.575±0.00 0.081±0.00 N/A 0.024±0.01 0.047±0.00 1.752±0.43
ENST00000467563 0.017±0.00 0.374±0.00 N/A 0.020±0.00 N/A 0.039±0.00 0.142±0.00 N/A N/A N/A N/A 0.018±0.00 N/A
ENST00000498043 N/A N/A N/A N/A N/A N/A N/A N/A 0.112±0.00 0.548±0.00 N/A 0.018±0.00 N/A
ENST00000615287 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.043±0.02 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00010A CIL_00010A_0001 CGP 20:63293186-63378401
CIL_0000X3 CIL_0000X3_0001 CGP 20:63343310-63472638

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001508 ISS action potential
GO:0001666 IDA response to hypoxia
GO:0004889 TAS acetylcholine-activated cation-selective channel activity
GO:0005216 IEA ion channel activity
GO:0005230 IEA extracellular ligand-gated ion channel activity
GO:0005515 IEA protein binding
GO:0005886 ISS plasma membrane
GO:0005892 IDA acetylcholine-gated channel complex
GO:0006281 IMP DNA repair
GO:0006810 IEA transport
GO:0006811 NAS:IEA ion transport
GO:0006816 ISS calcium ion transport
GO:0006979 IMP response to oxidative stress
GO:0007165 IDA signal transduction
GO:0007268 NAS synaptic transmission
GO:0007271 ISS synaptic transmission, cholinergic
GO:0007585 IEA respiratory gaseous exchange
GO:0007626 IEA locomotory behavior
GO:0009897 ISS external side of plasma membrane
GO:0014059 ISS regulation of dopamine secretion
GO:0015276 TAS ligand-gated ion channel activity
GO:0015464 IDA acetylcholine receptor activity
GO:0016020 ISS:IEA membrane
GO:0016021 NAS:IEA integral component of membrane
GO:0019233 ISS sensory perception of pain
GO:0030054 IEA cell junction
GO:0030425 ISS dendrite
GO:0034220 TAS ion transmembrane transport
GO:0035094 IDA response to nicotine
GO:0035095 IMP behavioral response to nicotine
GO:0035640 IEA exploration behavior
GO:0042113 ISS B cell activation
GO:0042166 IC acetylcholine binding
GO:0042391 ISS regulation of membrane potential
GO:0043025 ISS neuronal cell body
GO:0045211 IEA postsynaptic membrane
GO:0050877 IMP neurological system process
GO:0050890 IMP cognition
GO:0051899 ISS membrane depolarization
GO:0060080 ISS regulation of inhibitory postsynaptic membrane potential
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058393 chrna4b cholinergic receptor, nicotinic, alpha 4b protein_coding Danio_rerio
ENSDARG00000070724 chrna4b cholinergic receptor, nicotinic, alpha 4b protein_coding Danio_rerio
ENSDARG00000087071 CHRNA4 (3 of 3) cholinergic receptor, nicotinic, alpha 4 (neuronal) protein_coding Danio_rerio
ENSMUSG00000027577 Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 protein_coding Mus_musculus

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