C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nibrin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028224 Nbn 10090 + 4:15957925-15992589 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029879 Nbn-001 15957925-15992589 protein_coding
  ENSMUST00000149069 Nbn-002 15957967-15981554 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029879ENSMUST00000149069
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029879 1.982±0.82 11.591±1.57 9.399±1.51 4.230±0.58 1.975±1.27 3.485±1.26 1.662±0.18 2.039±0.50 4.885±3.57 2.102±0.71 4.004±0.66 7.148±3.47 6.101±1.39 2.283±1.95
ENSMUST00000149069 1.304±0.57 15.594±5.26 N/A 0.952±0.00 1.462±0.58 3.609±0.19 1.471±0.36 1.859±0.90 2.327±0.72 2.223±0.67 N/A 3.011±2.64 N/A 1.713±0.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00015K CIL_00015K_0002 CGP 4:15957925-16013888

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000077 ISO DNA damage checkpoint
GO:0000723 ISS telomere maintenance
GO:0000784 IEA nuclear chromosome, telomeric region
GO:0001701 IMP in utero embryonic development
GO:0001832 IMP blastocyst growth
GO:0003684 IDA damaged DNA binding
GO:0004003 IEA ATP-dependent DNA helicase activity
GO:0005634 IDA nucleus
GO:0005657 IDA replication fork
GO:0005730 IEA nucleolus
GO:0006302 ISS double-strand break repair
GO:0007093 ISS mitotic cell cycle checkpoint
GO:0007095 IMP:ISS mitotic G2 DNA damage checkpoint
GO:0008134 ISS transcription factor binding
GO:0008283 IMP cell proliferation
GO:0016605 IEA PML body
GO:0030870 ISS Mre11 complex
GO:0031954 IEA positive regulation of protein autophosphorylation
GO:0032508 IEA DNA duplex unwinding
GO:0033674 IEA positive regulation of kinase activity
GO:0035861 IEA site of double-strand break
GO:0042405 ISS nuclear inclusion body
GO:0045190 IDA isotype switching
GO:0047485 ISS protein N-terminus binding
GO:0048145 ISS regulation of fibroblast proliferation
GO:0050885 IMP neuromuscular process controlling balance
GO:0051321 IEA meiotic cell cycle
GO:0097193 IMP intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040303 nbn nibrin protein_coding Danio_rerio
ENSG00000104320 NBN nibrin protein_coding Homo_sapiens

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