C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nibrin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000104320 NBN 9606 - 8:89933336-90003228 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265433 NBN-001 89933336-89984716 protein_coding
  ENST00000396252 NBN-002 89933336-90003228 nonsense_mediated_decay
  ENST00000409330 NBN-003 89933484-89984404 protein_coding
  ENST00000474821 NBN-008 89935432-89937347 retained_intron
  ENST00000494804 NBN-006 89982404-89984665 retained_intron
  ENST00000517337 NBN-013 89978282-89984237 protein_coding
  ENST00000517772 NBN-011 89970520-89981655 protein_coding
  ENST00000519426 NBN-010 89970519-89984619 protein_coding
  ENST00000520325 NBN-012 89943359-89946625 retained_intron
  ENST00000523444 NBN-009 89978278-89984619 nonsense_mediated_decay
  ENST00000613033 NBN-014 89935171-89953354 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265433ENST00000396252ENST00000409330ENST00000517772
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265433 1.326±0.00 N/A 2.840±0.00 3.456±1.83 1.766±0.36 2.563±0.11 0.893±0.00 2.987±0.00 4.355±0.00 0.886±0.11 N/A 3.341±1.51 3.228±0.41 2.806±0.00
ENST00000396252 N/A 0.931±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000409330 3.140±0.00 2.931±0.00 N/A 1.529±0.00 7.670±0.00 4.549±0.00 2.090±0.70 8.366±0.00 2.576±0.70 4.447±1.12 2.621±0.00 3.828±1.28 2.973±0.00 6.100±0.66
ENST00000517772 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.811±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000077 IDA DNA damage checkpoint
GO:0000723 IMP telomere maintenance
GO:0000724 TAS double-strand break repair via homologous recombination
GO:0000784 IDA nuclear chromosome, telomeric region
GO:0001701 IEA in utero embryonic development
GO:0001832 IEA blastocyst growth
GO:0003684 IC damaged DNA binding
GO:0004003 IMP ATP-dependent DNA helicase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005657 IEA replication fork
GO:0005730 IDA nucleolus
GO:0006281 TAS DNA repair
GO:0006302 IDA double-strand break repair
GO:0007050 TAS cell cycle arrest
GO:0007093 IDA mitotic cell cycle checkpoint
GO:0007095 IDA mitotic G2 DNA damage checkpoint
GO:0008134 IPI transcription factor binding
GO:0008283 IEA cell proliferation
GO:0016605 IDA PML body
GO:0030174 TAS regulation of DNA-dependent DNA replication initiation
GO:0030330 TAS DNA damage response, signal transduction by p53 class mediator
GO:0030870 IDA Mre11 complex
GO:0031954 IDA positive regulation of protein autophosphorylation
GO:0032508 IMP DNA duplex unwinding
GO:0033674 IDA positive regulation of kinase activity
GO:0035861 IDA site of double-strand break
GO:0042405 IDA nuclear inclusion body
GO:0045190 IEA isotype switching
GO:0047485 IPI protein N-terminus binding
GO:0050885 IEA neuromuscular process controlling balance
GO:0051321 IEA meiotic cell cycle
GO:0097193 IEA intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040303 nbn nibrin protein_coding Danio_rerio
ENSMUSG00000028224 Nbn nibrin protein_coding Mus_musculus

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