C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Parkinson disease (autosomal recessive, early onset) 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028964 Park7 10090 - 4:150897133-150914437 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000030805 Park7-001 150897133-150909926 protein_coding
  ENSMUST00000105673 Park7-002 150897239-150909651 protein_coding
  ENSMUST00000105674 Park7-003 150897145-150909626 protein_coding
  ENSMUST00000105675 Park7-009 150897133-150914437 protein_coding
  ENSMUST00000105676 Park7-004 150897236-150908413 protein_coding
  ENSMUST00000128075 Park7-005 150901010-150909483 protein_coding
  ENSMUST00000132265 Park7-008 150897384-150901835 processed_transcript
  ENSMUST00000134751 Park7-006 150905126-150909868 protein_coding
  ENSMUST00000146184 Park7-010 150905250-150914206 protein_coding
  ENSMUST00000148626 Park7-007 150903559-150909828 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000030805ENSMUST00000105673ENSMUST00000105674ENSMUST00000105675ENSMUST00000105676ENSMUST00000134751
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000030805 99.261±27.57 17.700±3.69 125.727±12.77 88.802±24.47 33.663±13.49 23.539±4.31 69.969±6.59 181.912±16.27 112.445±38.74 53.692±1.81 342.618±28.56 38.498±22.14 48.363±29.94 32.369±9.17
ENSMUST00000105673 N/A N/A N/A N/A 10.789±0.00 N/A N/A N/A N/A N/A N/A 26.067±7.85 N/A 9.174±0.00
ENSMUST00000105674 N/A 46.884±5.40 N/A N/A 26.612±0.00 13.576±5.88 N/A N/A 33.147±0.70 N/A N/A 26.791±11.42 N/A N/A
ENSMUST00000105675 N/A 7.311±0.00 N/A N/A 21.107±6.04 10.763±4.48 N/A 34.972±0.00 22.035±0.00 N/A N/A 34.139±15.21 7.509±0.00 10.984±0.26
ENSMUST00000105676 27.311±4.86 N/A 28.591±3.38 27.091±0.00 41.725±0.00 N/A 20.736±2.43 63.410±0.00 47.659±13.27 23.694±0.00 N/A 65.700±21.81 22.757±7.40 17.496±2.70
ENSMUST00000134751 N/A N/A N/A 24.241±0.00 N/A N/A N/A N/A N/A N/A N/A 50.613±0.00 17.650±2.90 18.950±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007VW CIL_0007VW_0002 VISTA 4:150524120-151125978

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000785 IEA chromatin
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0001963 IMP synaptic transmission, dopaminergic
GO:0003713 IEA transcription coactivator activity
GO:0003723 TAS RNA binding
GO:0003729 ISS mRNA binding
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005739 IDA mitochondrion
GO:0005747 IEA mitochondrial respiratory chain complex I
GO:0005758 IDA mitochondrial intermembrane space
GO:0005759 IDA mitochondrial matrix
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006508 IEA proteolysis
GO:0006914 IEA autophagy
GO:0006954 IEA inflammatory response
GO:0007005 IMP mitochondrion organization
GO:0007338 IEA single fertilization
GO:0008134 IEA transcription factor binding
GO:0008233 ISS peptidase activity
GO:0008283 TAS cell proliferation
GO:0008344 IMP adult locomotory behavior
GO:0010628 IMP positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0016532 IEA superoxide dismutase copper chaperone activity
GO:0016605 IEA PML body
GO:0016684 IEA oxidoreductase activity, acting on peroxide as acceptor
GO:0018323 IMP enzyme active site formation via L-cysteine sulfinic acid
GO:0019172 IDA glyoxalase III activity
GO:0019243 IDA methylglyoxal catabolic process to D-lactate
GO:0019249 IDA lactate biosynthetic process
GO:0019899 IEA enzyme binding
GO:0019955 IEA cytokine binding
GO:0031397 IMP negative regulation of protein ubiquitination
GO:0032091 ISS negative regulation of protein binding
GO:0032435 IEA negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032757 IEA positive regulation of interleukin-8 production
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0033234 IEA negative regulation of protein sumoylation
GO:0034599 IMP cellular response to oxidative stress
GO:0034614 IMP cellular response to reactive oxygen species
GO:0036470 IEA tyrosine 3-monooxygenase activator activity
GO:0036471 IMP cellular response to glyoxal
GO:0036478 IEA L-dopa decarboxylase activator activity
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042542 IDA response to hydrogen peroxide
GO:0042743 IMP hydrogen peroxide metabolic process
GO:0042802 IEA identical protein binding
GO:0042803 ISS protein homodimerization activity
GO:0043005 IDA neuron projection
GO:0043066 IMP negative regulation of apoptotic process
GO:0043523 ISS regulation of neuron apoptotic process
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0044297 IDA cell body
GO:0044388 IEA small protein activating enzyme binding
GO:0044390 IEA small protein conjugating enzyme binding
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046295 IDA glycolate biosynthetic process
GO:0046826 IEA negative regulation of protein export from nucleus
GO:0050681 IEA androgen receptor binding
GO:0050727 IMP regulation of inflammatory response
GO:0050821 IMP protein stabilization
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051444 IC negative regulation of ubiquitin-protein transferase activity
GO:0051583 IMP dopamine uptake involved in synaptic transmission
GO:0051881 IEA regulation of mitochondrial membrane potential
GO:0051899 IMP membrane depolarization
GO:0051920 IMP peroxiredoxin activity
GO:0055114 IMP oxidation-reduction process
GO:0060081 IMP membrane hyperpolarization
GO:0060548 IMP negative regulation of cell death
GO:0060765 IEA regulation of androgen receptor signaling pathway
GO:0070062 IEA extracellular vesicular exosome
GO:0070301 IMP cellular response to hydrogen peroxide
GO:0070491 IEA repressing transcription factor binding
GO:0090073 IEA positive regulation of protein homodimerization activity
GO:0097110 IEA scaffold protein binding
GO:1900182 IEA positive regulation of protein localization to nucleus
GO:1901215 IEA negative regulation of neuron death
GO:1901671 IEA positive regulation of superoxide dismutase activity
GO:1901984 IEA negative regulation of protein acetylation
GO:1902958 IMP positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903094 IEA negative regulation of protein K48-linked deubiquitination
GO:1903122 IEA negative regulation of TRAIL-activated apoptotic signaling pathway
GO:1903135 IEA cupric ion binding
GO:1903136 IEA cuprous ion binding
GO:1903168 IEA positive regulation of pyrroline-5-carboxylate reductase activity
GO:1903178 IEA positive regulation of tyrosine 3-monooxygenase activity
GO:1903190 IDA glyoxal catabolic process
GO:1903197 IEA positive regulation of L-dopa biosynthetic process
GO:1903200 IEA positive regulation of L-dopa decarboxylase activity
GO:1903202 IEA negative regulation of oxidative stress-induced cell death
GO:1903204 IMP negative regulation of oxidative stress-induced neuron death
GO:1903206 IEA negative regulation of hydrogen peroxide-induced cell death
GO:1903208 IMP negative regulation of hydrogen peroxide-induced neuron death
GO:1903377 IEA negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990381 IEA ubiquitin-specific protease binding
GO:1990422 IDA glyoxalase (glycolic acid-forming) activity
GO:2000157 IEA negative regulation of ubiquitin-specific protease activity
GO:2000277 IMP positive regulation of oxidative phosphorylation uncoupler activity
GO:2000679 IEA positive regulation of transcription regulatory region DNA binding
GO:2000825 IEA positive regulation of androgen receptor activity
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway
GO:2001268 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000034826 park7 parkinson disease (autosomal recessive, early onset) 7 protein_coding Danio_rerio
ENSG00000116288 PARK7 parkinson protein 7 protein_coding Homo_sapiens

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