C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Parkinson disease (autosomal recessive, early onset) 7
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000105674 Park7-003 ENSMUSG00000028964 10090 - 4:150897145-150909626 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBreastColonLiverOvaryENSMUST00000105674
Transcript ID Adrenal Breast Colon Liver Ovary
ENSMUST00000105674 46.884±5.40 26.612±0.00 13.576±5.88 33.147±0.70 26.791±11.42

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007VW CIL_0007VW_0002 VISTA 4:150524120-151125978

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000785 IEA chromatin
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0001963 IMP synaptic transmission, dopaminergic
GO:0003713 IEA transcription coactivator activity
GO:0003723 TAS RNA binding
GO:0003729 ISS mRNA binding
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005739 IDA mitochondrion
GO:0005747 IEA mitochondrial respiratory chain complex I
GO:0005758 IDA mitochondrial intermembrane space
GO:0005759 IDA mitochondrial matrix
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006508 IEA proteolysis
GO:0006914 IEA autophagy
GO:0006954 IEA inflammatory response
GO:0007005 IMP mitochondrion organization
GO:0007338 IEA single fertilization
GO:0008134 IEA transcription factor binding
GO:0008233 ISS peptidase activity
GO:0008283 TAS cell proliferation
GO:0008344 IMP adult locomotory behavior
GO:0010628 IMP positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0016532 IEA superoxide dismutase copper chaperone activity
GO:0016605 IEA PML body
GO:0016684 IEA oxidoreductase activity, acting on peroxide as acceptor
GO:0018323 IMP enzyme active site formation via L-cysteine sulfinic acid
GO:0019172 IDA glyoxalase III activity
GO:0019243 IDA methylglyoxal catabolic process to D-lactate
GO:0019249 IDA lactate biosynthetic process
GO:0019899 IEA enzyme binding
GO:0019955 IEA cytokine binding
GO:0031397 IMP negative regulation of protein ubiquitination
GO:0032091 ISS negative regulation of protein binding
GO:0032435 IEA negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032757 IEA positive regulation of interleukin-8 production
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0033234 IEA negative regulation of protein sumoylation
GO:0034599 IMP cellular response to oxidative stress
GO:0034614 IMP cellular response to reactive oxygen species
GO:0036470 IEA tyrosine 3-monooxygenase activator activity
GO:0036471 IMP cellular response to glyoxal
GO:0036478 IEA L-dopa decarboxylase activator activity
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042542 IDA response to hydrogen peroxide
GO:0042743 IMP hydrogen peroxide metabolic process
GO:0042802 IEA identical protein binding
GO:0042803 ISS protein homodimerization activity
GO:0043005 IDA neuron projection
GO:0043066 IMP negative regulation of apoptotic process
GO:0043523 ISS regulation of neuron apoptotic process
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0044297 IDA cell body
GO:0044388 IEA small protein activating enzyme binding
GO:0044390 IEA small protein conjugating enzyme binding
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046295 IDA glycolate biosynthetic process
GO:0046826 IEA negative regulation of protein export from nucleus
GO:0050681 IEA androgen receptor binding
GO:0050727 IMP regulation of inflammatory response
GO:0050821 IMP protein stabilization
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051444 IC negative regulation of ubiquitin-protein transferase activity
GO:0051583 IMP dopamine uptake involved in synaptic transmission
GO:0051881 IEA regulation of mitochondrial membrane potential
GO:0051899 IMP membrane depolarization
GO:0051920 IMP peroxiredoxin activity
GO:0055114 IMP oxidation-reduction process
GO:0060081 IMP membrane hyperpolarization
GO:0060548 IMP negative regulation of cell death
GO:0060765 IEA regulation of androgen receptor signaling pathway
GO:0070062 IEA extracellular vesicular exosome
GO:0070301 IMP cellular response to hydrogen peroxide
GO:0070491 IEA repressing transcription factor binding
GO:0090073 IEA positive regulation of protein homodimerization activity
GO:0097110 IEA scaffold protein binding
GO:1900182 IEA positive regulation of protein localization to nucleus
GO:1901215 IEA negative regulation of neuron death
GO:1901671 IEA positive regulation of superoxide dismutase activity
GO:1901984 IEA negative regulation of protein acetylation
GO:1902958 IMP positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903094 IEA negative regulation of protein K48-linked deubiquitination
GO:1903122 IEA negative regulation of TRAIL-activated apoptotic signaling pathway
GO:1903135 IEA cupric ion binding
GO:1903136 IEA cuprous ion binding
GO:1903168 IEA positive regulation of pyrroline-5-carboxylate reductase activity
GO:1903178 IEA positive regulation of tyrosine 3-monooxygenase activity
GO:1903190 IDA glyoxal catabolic process
GO:1903197 IEA positive regulation of L-dopa biosynthetic process
GO:1903200 IEA positive regulation of L-dopa decarboxylase activity
GO:1903202 IEA negative regulation of oxidative stress-induced cell death
GO:1903204 IMP negative regulation of oxidative stress-induced neuron death
GO:1903206 IEA negative regulation of hydrogen peroxide-induced cell death
GO:1903208 IMP negative regulation of hydrogen peroxide-induced neuron death
GO:1903377 IEA negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990381 IEA ubiquitin-specific protease binding
GO:1990422 IDA glyoxalase (glycolic acid-forming) activity
GO:2000157 IEA negative regulation of ubiquitin-specific protease activity
GO:2000277 IMP positive regulation of oxidative phosphorylation uncoupler activity
GO:2000679 IEA positive regulation of transcription regulatory region DNA binding
GO:2000825 IEA positive regulation of androgen receptor activity
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway
GO:2001268 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000338639 PARK7-002 protein_coding Homo_sapiens 0 571
ENST00000377488 PARK7-006 protein_coding Homo_sapiens 0 571
ENST00000377491 PARK7-005 protein_coding Homo_sapiens 0 571
ENST00000377493 PARK7-003 protein_coding Homo_sapiens 0 224
ENST00000460192 PARK7-007 retained_intron Homo_sapiens 0 224
ENST00000465354 PARK7-008 retained_intron Homo_sapiens 0 372
ENST00000493373 PARK7-004 protein_coding Homo_sapiens 0 562
ENST00000493678 PARK7-001 protein_coding Homo_sapiens 0 571
ENST00000497113 PARK7-009 processed_transcript Homo_sapiens 0 374

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