C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: platelet derived growth factor receptor, alpha polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029231 Pdgfra 10090 + 5:75152291-75198204 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000000476 Pdgfra-201 75152291-75198204 protein_coding
  ENSMUST00000168162 Pdgfra-202 75156166-75198204 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000000476ENSMUST00000168162
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000000476 14.493±8.57 2.368±0.54 11.856±0.15 3.545±1.83 12.888±3.02 10.392±1.15 4.050±1.63 8.427±1.47 0.671±0.17 40.581±4.81 0.775±0.36 9.388±3.83 7.136±4.99 1.432±0.48
ENSMUST00000168162 3.264±1.67 1.107±0.32 2.990±0.59 0.944±0.58 2.262±0.44 1.537±0.00 1.140±0.09 1.224±0.18 0.207±0.06 4.670±0.01 0.947±0.37 7.621±3.37 11.372±7.74 0.402±0.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007R1 CIL_0007R1_0002 VISTA 5:74712461-75313668
CIL_0008IT CIL_0008IT_0002 VISTA 5:74771388-75372201
CIL_0001CO CIL_0001CO_0002 CGP 5:75075464-75198204
CIL_0001CJ CIL_0001CJ_0002 CGP 5:75152291-75656722

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001553 IGI luteinization
GO:0001701 IMP in utero embryonic development
GO:0002244 IMP hematopoietic progenitor cell differentiation
GO:0005018 ISS platelet-derived growth factor alpha-receptor activity
GO:0005021 ISS vascular endothelial growth factor-activated receptor activity
GO:0005161 IEA platelet-derived growth factor receptor binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005887 ISS integral component of plasma membrane
GO:0005902 IDA microvillus
GO:0007204 ISS positive regulation of cytosolic calcium ion concentration
GO:0008210 IGI estrogen metabolic process
GO:0008284 ISS positive regulation of cell proliferation
GO:0008585 IGI female gonad development
GO:0009653 IMP anatomical structure morphogenesis
GO:0009887 IMP organ morphogenesis
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010544 ISS negative regulation of platelet activation
GO:0010863 IEA positive regulation of phospholipase C activity
GO:0016020 IEA membrane
GO:0016477 IMP cell migration
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0023019 IDA signal transduction involved in regulation of gene expression
GO:0030198 IMP extracellular matrix organization
GO:0030324 IMP lung development
GO:0030325 IGI adrenal gland development
GO:0030335 ISS positive regulation of cell migration
GO:0030539 IMP male genitalia development
GO:0031226 IEA intrinsic component of plasma membrane
GO:0033327 IMP Leydig cell differentiation
GO:0035790 IDA platelet-derived growth factor receptor-alpha signaling pathway
GO:0038085 IEA vascular endothelial growth factor binding
GO:0038091 ISS positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0042060 IMP wound healing
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0042803 ISS protein homodimerization activity
GO:0043552 ISS positive regulation of phosphatidylinositol 3-kinase activity
GO:0045740 ISS positive regulation of DNA replication
GO:0046777 ISS protein autophosphorylation
GO:0048008 IMP platelet-derived growth factor receptor signaling pathway
GO:0048015 ISS phosphatidylinositol-mediated signaling
GO:0048146 ISS positive regulation of fibroblast proliferation
GO:0048407 IDA platelet-derived growth factor binding
GO:0048557 IMP embryonic digestive tract morphogenesis
GO:0048701 IMP embryonic cranial skeleton morphogenesis
GO:0048705 IMP skeletal system morphogenesis
GO:0050920 IEA regulation of chemotaxis
GO:0055003 IGI cardiac myofibril assembly
GO:0060021 IMP palate development
GO:0060325 IMP face morphogenesis
GO:0060326 IMP cell chemotaxis
GO:0061298 IGI retina vasculature development in camera-type eye
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0070527 ISS platelet aggregation
GO:0071230 IDA cellular response to amino acid stimulus
GO:0072277 IGI metanephric glomerular capillary formation
GO:2000739 ISS regulation of mesenchymal stem cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000134853 PDGFRA platelet-derived growth factor receptor, alpha polypeptide protein_coding Homo_sapiens

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