C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: RE1-silencing transcription factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029249 Rest 10090 + 5:77265491-77286432 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000080359 Rest-001 77265491-77286432 protein_coding
  ENSMUST00000113449 Rest-002 77266196-77286432 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000080359ENSMUST00000113449
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000080359 4.022±2.06 7.431±0.84 4.129±0.30 1.741±1.15 5.152±1.67 4.604±0.48 1.529±0.44 4.229±0.42 2.239±0.42 5.822±0.50 0.791±0.30 6.316±1.88 7.053±3.02 1.584±0.96
ENSMUST00000113449 0.987±0.23 0.997±0.00 2.063±0.22 0.411±0.03 1.744±1.46 0.768±0.08 0.832±0.41 0.983±0.26 0.948±0.37 N/A 0.829±0.11 2.690±1.24 4.998±2.07 1.046±0.31

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008G9 CIL_0008G9_0002 VISTA 5:76829880-77430993
CIL_0001WS CIL_0001WS_0002 CGP 5:77205107-77286432
CIL_0003EC CIL_0003EC_0003 CGP 5:77265491-77310084

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001046 IEA core promoter sequence-specific DNA binding
GO:0001047 ISS core promoter binding
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0002244 IMP hematopoietic progenitor cell differentiation
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005829 IDA cytosol
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0008134 IEA transcription factor binding
GO:0008285 ISS negative regulation of cell proliferation
GO:0010629 ISS negative regulation of gene expression
GO:0015271 ISS outward rectifier potassium channel activity
GO:0017053 IDA transcriptional repressor complex
GO:0032348 ISS negative regulation of aldosterone biosynthetic process
GO:0035690 ISS cellular response to drug
GO:0043065 ISS positive regulation of apoptotic process
GO:0043280 ISS positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043922 ISS negative regulation by host of viral transcription
GO:0044212 ISS transcription regulatory region DNA binding
GO:0045665 ISS negative regulation of neuron differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045955 ISS negative regulation of calcium ion-dependent exocytosis
GO:0046676 ISS negative regulation of insulin secretion
GO:0046872 IEA metal ion binding
GO:0050768 IGI negative regulation of neurogenesis
GO:0060379 IDA cardiac muscle cell myoblast differentiation
GO:0070933 ISS histone H4 deacetylation
GO:0071257 ISS cellular response to electrical stimulus
GO:0071385 ISS cellular response to glucocorticoid stimulus
GO:0071805 IEA potassium ion transmembrane transport
GO:2000065 ISS negative regulation of cortisol biosynthetic process
GO:2000706 ISS negative regulation of dense core granule biogenesis
GO:2000740 IEA negative regulation of mesenchymal stem cell differentiation
GO:2000798 ISS negative regulation of amniotic stem cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007222 rest RE1-silencing transcription factor protein_coding Danio_rerio
ENSG00000084093 REST RE1-silencing transcription factor protein_coding Homo_sapiens

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