C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: RE1-silencing transcription factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000084093 REST 9606 + 4:56907876-56935844 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000309042 REST-001 56907909-56935844 protein_coding
  ENST00000503522 REST-003 56909190-56910688 processed_transcript
  ENST00000511065 REST-002 56908913-56911015 retained_intron
  ENST00000514063 REST-004 56911212-56929959 processed_transcript
  ENST00000611211 REST-201 56909016-56929878 protein_coding
  ENST00000612429 REST-202 56907876-56922378 protein_coding
  ENST00000616975 REST-203 56907876-56927655 protein_coding
  ENST00000619101 REST-204 56908913-56935836 protein_coding
  ENST00000622863 REST-205 56908094-56932184 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000309042ENST00000611211ENST00000616975ENST00000619101
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000309042 2.728±0.00 1.390±0.00 1.540±0.00 0.275±0.05 3.136±0.00 1.453±0.38 1.964±0.36 1.104±0.44 1.150±0.00 1.328±0.34 1.000±0.77 2.347±0.46 N/A 2.833±0.00
ENST00000611211 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.339±0.00 N/A N/A N/A
ENST00000616975 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.888±0.00 N/A N/A N/A
ENST00000619101 1.244±0.00 0.844±0.00 2.650±0.00 1.057±0.39 3.093±0.35 3.273±0.00 0.825±0.00 2.156±0.17 3.683±2.74 2.934±1.96 0.307±0.00 1.988±1.16 2.178±1.61 5.434±2.54

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008G9 CIL_0008G9_0001 VISTA 4:56396035-56999166
CIL_0001WS CIL_0001WS_0001 CGP 4:56809860-56935844
CIL_0003EC CIL_0003EC_0002 CGP 4:56907876-56978823

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001047 IDA core promoter binding
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0002244 IEA hematopoietic progenitor cell differentiation
GO:0003677 IEA DNA binding
GO:0003682 ISS chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005829 IEA cytosol
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0008134 IPI transcription factor binding
GO:0008285 IMP negative regulation of cell proliferation
GO:0010629 IMP negative regulation of gene expression
GO:0015271 IMP outward rectifier potassium channel activity
GO:0017053 IDA transcriptional repressor complex
GO:0032348 IMP negative regulation of aldosterone biosynthetic process
GO:0035690 IMP cellular response to drug
GO:0043065 IMP positive regulation of apoptotic process
GO:0043280 IMP positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043922 IDA negative regulation by host of viral transcription
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045665 IMP negative regulation of neuron differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045955 ISS negative regulation of calcium ion-dependent exocytosis
GO:0046676 IMP negative regulation of insulin secretion
GO:0046872 IEA metal ion binding
GO:0050768 ISS negative regulation of neurogenesis
GO:0060379 ISS cardiac muscle cell myoblast differentiation
GO:0070933 IDA histone H4 deacetylation
GO:0071257 IMP cellular response to electrical stimulus
GO:0071385 IDA cellular response to glucocorticoid stimulus
GO:0071805 IMP potassium ion transmembrane transport
GO:2000065 IMP negative regulation of cortisol biosynthetic process
GO:2000706 ISS negative regulation of dense core granule biogenesis
GO:2000740 IMP negative regulation of mesenchymal stem cell differentiation
GO:2000798 IMP negative regulation of amniotic stem cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007222 rest RE1-silencing transcription factor protein_coding Danio_rerio
ENSMUSG00000029249 Rest RE1-silencing transcription factor protein_coding Mus_musculus

Loading