C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pancreatic and duodenal homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029644 Pdx1 10090 + 5:147269959-147278008 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000085591 Pdx1-001 147269959-147278008 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; ColonLiverOvaryPlacentaTestisENSMUST00000085591
Transcript ID Colon Liver Ovary Placenta Testis
ENSMUST00000085591 0.300±0.09 0.013±0.01 0.068±0.04 0.012±0.00 0.016±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008CO CIL_0008CO_0002 VISTA 5:146855041-147456530
CIL_00082E CIL_00082E_0002 VISTA 5:146922660-147524221
CIL_0007MT CIL_0007MT_0002 UCNEbase 5:146994099-147547626
CIL_0003F7 CIL_0003F7_0002 CGP 5:147188696-147278008

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046 IEA core promoter sequence-specific DNA binding
GO:0001077 IC RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001889 IMP liver development
GO:0003309 IEA type B pancreatic cell differentiation
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006006 IDA glucose metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007224 IEA smoothened signaling pathway
GO:0007263 IEA nitric oxide mediated signal transduction
GO:0007417 IEA central nervous system development
GO:0008134 IEA transcription factor binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0009611 IEA response to wounding
GO:0009749 IEA response to glucose
GO:0010040 IEA response to iron(II) ion
GO:0010157 IEA response to chlorate
GO:0010260 IEA organ senescence
GO:0010942 IEA positive regulation of cell death
GO:0014070 IEA response to organic cyclic compound
GO:0016331 IMP morphogenesis of embryonic epithelium
GO:0030073 IEA insulin secretion
GO:0030154 IMP cell differentiation
GO:0031016 IMP pancreas development
GO:0031017 IMP exocrine pancreas development
GO:0031018 IMP endocrine pancreas development
GO:0031100 IEA organ regeneration
GO:0031667 IEA response to nutrient levels
GO:0032024 IEA positive regulation of insulin secretion
GO:0032403 IEA protein complex binding
GO:0033273 IEA response to vitamin
GO:0033993 IEA response to lipid
GO:0034097 IEA response to cytokine
GO:0035094 IEA response to nicotine
GO:0042127 IDA regulation of cell proliferation
GO:0042493 IEA response to drug
GO:0042593 IMP glucose homeostasis
GO:0043201 IEA response to leucine
GO:0043279 IEA response to alkaloid
GO:0043388 IEA positive regulation of DNA binding
GO:0043565 IDA sequence-specific DNA binding
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0048565 IMP digestive tract development
GO:0048863 IEA stem cell differentiation
GO:0051384 IEA response to glucocorticoid
GO:0051594 IEA detection of glucose
GO:0060290 IEA transdifferentiation
GO:0070542 IEA response to fatty acid
GO:1902236 IMP negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2000675 IMP negative regulation of type B pancreatic cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002779 pdx1 pancreatic and duodenal homeobox 1 protein_coding Danio_rerio
ENSG00000139515 PDX1 pancreatic and duodenal homeobox 1 protein_coding Homo_sapiens

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