C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: FMS-like tyrosine kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000029648 Flt1 10090 - 5:147561604-147726011 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000031652 Flt1-003 147654269-147725988 protein_coding
  ENSMUST00000031653 Flt1-001 147561604-147726011 protein_coding
  ENSMUST00000110529 Flt1-002 147635159-147725988 protein_coding
  ENSMUST00000125272 Flt1-005 147604660-147634418 processed_transcript
  ENSMUST00000142477 Flt1-004 147614756-147615242 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000031652ENSMUST00000031653ENSMUST00000110529
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000031652 3.408±1.03 8.526±3.19 N/A N/A 4.098±0.49 1.015±0.36 N/A N/A N/A 10.316±0.00 N/A 2.811±0.66 N/A N/A
ENSMUST00000031653 7.509±3.14 3.871±0.85 3.095±0.38 2.699±2.48 3.497±0.78 1.513±0.44 8.084±0.23 6.972±0.21 0.718±0.20 16.989±2.12 5.663±0.54 2.390±0.99 10.291±0.66 0.591±0.15
ENSMUST00000110529 2.138±0.48 1.781±0.24 1.792±0.17 1.601±0.90 1.121±0.15 0.574±0.13 2.527±0.57 2.006±0.14 0.328±0.16 5.154±0.76 2.536±0.23 1.077±0.37 87.446±58.28 0.135±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000G1 CIL_0000G1_0003 CGP 5:147430161-147726011
CIL_0004CL CIL_0004CL_0002 CGP 5:147561604-147875778

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IMP angiogenesis
GO:0001569 IMP patterning of blood vessels
GO:0002040 IMP sprouting angiogenesis
GO:0002548 IEA monocyte chemotaxis
GO:0005021 IDA vascular endothelial growth factor-activated receptor activity
GO:0005524 IEA ATP binding
GO:0005768 IEA endosome
GO:0005887 IEA integral component of plasma membrane
GO:0005925 IEA focal adhesion
GO:0006468 IEA protein phosphorylation
GO:0010863 IEA positive regulation of phospholipase C activity
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477 IGI cell migration
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0019838 IEA growth factor binding
GO:0030154 IEA cell differentiation
GO:0030335 IEA positive regulation of cell migration
GO:0030949 IEA positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035924 IEA cellular response to vascular endothelial growth factor stimulus
GO:0036323 IEA vascular endothelial growth factor receptor-1 signaling pathway
GO:0036326 IEA VEGF-A-activated receptor activity
GO:0036327 IEA VEGF-B-activated receptor activity
GO:0036332 IEA placental growth factor-activated receptor activity
GO:0038084 IEA vascular endothelial growth factor signaling pathway
GO:0042802 IPI identical protein binding
GO:0043235 ISO receptor complex
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043552 IEA positive regulation of phosphatidylinositol 3-kinase activity
GO:0045766 IEA positive regulation of angiogenesis
GO:0046777 ISS protein autophosphorylation
GO:0048010 IC vascular endothelial growth factor receptor signaling pathway
GO:0048514 IMP blood vessel morphogenesis
GO:0048598 IMP embryonic morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019371 flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) protein_coding Danio_rerio
ENSG00000102755 FLT1 fms-related tyrosine kinase 1 protein_coding Homo_sapiens

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