C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fms-related tyrosine kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000102755 FLT1 9606 - 13:28300344-28495128 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000282397 FLT1-001 28300344-28495095 protein_coding
  ENST00000539099 FLT1-201 28399044-28495128 protein_coding
  ENST00000540678 FLT1-202 28303144-28346289 protein_coding
  ENST00000541932 FLT1-003 28368096-28495128 protein_coding
  ENST00000543394 FLT1-203 28303134-28322633 protein_coding
  ENST00000615611 FLT1-204 28303126-28328415 protein_coding
  ENST00000615840 FLT1-002 28385548-28495079 protein_coding
  ENST00000617835 FLT1-205 28303126-28308434 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000282397ENST00000541932ENST00000615840
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000282397 17.613±0.00 3.603±0.00 5.030±0.00 2.663±1.21 4.395±0.24 8.827±6.78 6.430±3.21 2.989±1.60 2.146±0.18 9.380±3.33 1.270±0.79 2.064±0.58 N/A 1.677±1.00
ENST00000541932 N/A N/A 2.601±0.00 N/A 2.947±0.00 N/A 4.899±0.00 2.717±0.00 2.449±0.00 5.798±0.00 N/A 3.834±0.00 337.504±159.00 1.797±0.00
ENST00000615840 27.339±0.00 4.819±0.00 N/A 4.196±3.27 3.055±0.17 16.836±16.17 4.298±2.21 2.725±2.23 2.038±0.03 16.042±10.19 5.327±0.00 2.614±0.77 86.349±34.17 1.850±1.15

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000G1 CIL_0000G1_0002 CGP 13:28138506-28495128
CIL_0004CL CIL_0004CL_0001 CGP 13:28300344-28678925

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001569 IEA patterning of blood vessels
GO:0002040 IEA sprouting angiogenesis
GO:0002548 IDA monocyte chemotaxis
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 TAS transmembrane receptor protein tyrosine kinase activity
GO:0005021 IMP vascular endothelial growth factor-activated receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005615 TAS extracellular space
GO:0005768 IEA endosome
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005925 IDA focal adhesion
GO:0006468 IEA protein phosphorylation
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284 TAS positive regulation of cell proliferation
GO:0010863 IMP positive regulation of phospholipase C activity
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477 IMP cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019838 IPI growth factor binding
GO:0030154 IEA cell differentiation
GO:0030335 IDA positive regulation of cell migration
GO:0030949 IDA positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035924 IDA cellular response to vascular endothelial growth factor stimulus
GO:0036323 IDA vascular endothelial growth factor receptor-1 signaling pathway
GO:0036326 IDA VEGF-A-activated receptor activity
GO:0036327 IDA VEGF-B-activated receptor activity
GO:0036332 IDA placental growth factor-activated receptor activity
GO:0038084 IEA vascular endothelial growth factor signaling pathway
GO:0042802 IEA identical protein binding
GO:0043235 IDA receptor complex
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043410 IDA positive regulation of MAPK cascade
GO:0043552 IMP positive regulation of phosphatidylinositol 3-kinase activity
GO:0045766 IMP positive regulation of angiogenesis
GO:0046777 IDA protein autophosphorylation
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0048514 ISS blood vessel morphogenesis
GO:0048598 ISS embryonic morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019371 flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) protein_coding Danio_rerio
ENSMUSG00000029648 Flt1 FMS-like tyrosine kinase 1 protein_coding Mus_musculus

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