C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030209 Grin2b 10090 - 6:135713232-136173511 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000053880 Grin2b-001 135713232-136171722 protein_coding
  ENSMUST00000111905 Grin2b-201 135729826-136173511 protein_coding
  ENSMUST00000125905 Grin2b-004 136044196-136173511 protein_coding
  ENSMUST00000143943 Grin2b-003 136044196-136173511 protein_coding
  ENSMUST00000152012 Grin2b-002 135869703-136173511 processed_transcript
  ENSMUST00000188999 Grin2b-005 136044203-136171889 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000053880ENSMUST00000111905ENSMUST00000152012ENSMUST00000188999
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000053880 0.047±0.02 0.010±0.00 0.001±0.00 5.354±3.71 0.012±0.01 0.026±0.01 0.005±0.00 0.002±0.00 0.004±0.00 0.014±0.01 0.002±0.00 0.197±0.07 0.002±0.00 N/A
ENSMUST00000111905 N/A N/A 0.003±0.00 N/A N/A 0.032±0.00 N/A 0.017±0.02 0.022±0.02 0.009±0.01 N/A 0.092±0.03 0.003±0.00 2.913±1.64
ENSMUST00000152012 N/A 0.024±0.00 0.002±0.00 N/A 0.064±0.05 0.064±0.04 N/A N/A N/A 0.128±0.00 N/A 0.449±0.15 N/A N/A
ENSMUST00000188999 N/A N/A N/A N/A N/A 0.723±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003H7 CIL_0003H7_0002 CGP 6:135362931-136173511

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001662 IMP behavioral fear response
GO:0001701 IMP in utero embryonic development
GO:0001964 IMP startle response
GO:0001967 IMP suckling behavior
GO:0004972 IMP N-methyl-D-aspartate selective glutamate receptor activity
GO:0005234 IBA extracellular-glutamate-gated ion channel activity
GO:0005261 IGI cation channel activity
GO:0005262 IMP calcium channel activity
GO:0005515 IPI protein binding
GO:0006812 IGI cation transport
GO:0006816 IMP calcium ion transport
GO:0007268 IMP synaptic transmission
GO:0007423 IMP sensory organ development
GO:0007612 IDA learning
GO:0007613 IDA memory
GO:0008021 IDA synaptic vesicle
GO:0010738 IMP regulation of protein kinase A signaling
GO:0014069 IDA postsynaptic density
GO:0016020 IDA membrane
GO:0016594 IEA glycine binding
GO:0017146 IPI N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 IEA cell junction
GO:0034220 IBA ion transmembrane transport
GO:0035235 IEA ionotropic glutamate receptor signaling pathway
GO:0035249 IBA synaptic transmission, glutamatergic
GO:0042596 IMP fear response
GO:0045202 IDA synapse
GO:0045211 IDA postsynaptic membrane
GO:0045471 IMP response to ethanol
GO:0048167 IMP regulation of synaptic plasticity
GO:0048266 IMP behavioral response to pain
GO:0050966 IMP detection of mechanical stimulus involved in sensory perception of pain
GO:0060078 IMP regulation of postsynaptic membrane potential
GO:0060079 IMP regulation of excitatory postsynaptic membrane potential
GO:0070588 IMP calcium ion transmembrane transport
GO:0097481 IDA neuronal postsynaptic density
GO:0098655 IGI cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030376 grin2bb glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b protein_coding Danio_rerio
ENSDARG00000079348 GRIN2B (2 of 2) glutamate receptor, ionotropic, N-methyl D-aspartate 2B protein_coding Danio_rerio
ENSG00000273079 GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B protein_coding Homo_sapiens

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