C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000273079 GRIN2B 9606 - 12:13537337-13980119 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000609686 GRIN2B-001 13537337-13980119 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000609686
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000609686 0.021±0.00 0.213±0.00 0.032±0.00 5.611±0.00 0.261±0.23 0.019±0.01 0.007±0.00 0.027±0.00 0.020±0.01 0.025±0.02 0.198±0.19 0.003±0.00 0.072±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003H7 CIL_0003H7_0001 CGP 12:13196716-13980119
CIL_0006XF CIL_0006XF_0002 CGP 12:13537337-14502935

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001662 IEA behavioral fear response
GO:0001701 IEA in utero embryonic development
GO:0001964 IEA startle response
GO:0001967 IEA suckling behavior
GO:0004970 IEA ionotropic glutamate receptor activity
GO:0004972 IBA N-methyl-D-aspartate selective glutamate receptor activity
GO:0005234 IBA:IEA extracellular-glutamate-gated ion channel activity
GO:0005261 IEA cation channel activity
GO:0005262 IEA calcium channel activity
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006810 TAS transport
GO:0006812 IEA cation transport
GO:0006816 IEA calcium ion transport
GO:0007215 TAS glutamate receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0007423 IEA sensory organ development
GO:0007611 TAS learning or memory
GO:0007612 IEA learning
GO:0007613 IEA memory
GO:0008021 IEA synaptic vesicle
GO:0008270 ISS zinc ion binding
GO:0009986 ISS cell surface
GO:0010738 IEA regulation of protein kinase A signaling
GO:0014069 IEA postsynaptic density
GO:0016020 IEA membrane
GO:0016594 IDA glycine binding
GO:0017146 IDA N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 IEA cell junction
GO:0030425 IBA dendrite
GO:0034220 IBA ion transmembrane transport
GO:0035235 IBA ionotropic glutamate receptor signaling pathway
GO:0035249 IBA synaptic transmission, glutamatergic
GO:0042596 IEA fear response
GO:0043005 ISS neuron projection
GO:0045202 IEA synapse
GO:0045211 IBA postsynaptic membrane
GO:0045471 IDA response to ethanol
GO:0048167 IEA regulation of synaptic plasticity
GO:0048266 IEA behavioral response to pain
GO:0050966 IEA detection of mechanical stimulus involved in sensory perception of pain
GO:0060078 IEA regulation of postsynaptic membrane potential
GO:0060079 IEA regulation of excitatory postsynaptic membrane potential
GO:0070588 IEA calcium ion transmembrane transport
GO:0097481 IEA neuronal postsynaptic density
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030376 grin2bb glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b protein_coding Danio_rerio
ENSDARG00000079348 GRIN2B (2 of 2) glutamate receptor, ionotropic, N-methyl D-aspartate 2B protein_coding Danio_rerio
ENSMUSG00000030209 Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) protein_coding Mus_musculus

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