C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibroblast growth factor receptor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030849 Fgfr2 10090 - 7:130162451-133123350 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000117073 Fgfr2-020 130163959-130261857 protein_coding
  ENSMUST00000117089 Fgfr2-012 130163959-130261857 protein_coding
  ENSMUST00000117357 Fgfr2-016 130163959-130261857 protein_coding
  ENSMUST00000117691 Fgfr2-013 130163959-130261857 protein_coding
  ENSMUST00000117754 Fgfr2-009 130163959-130261857 protein_coding
  ENSMUST00000117858 Fgfr2-014 130163959-130261857 protein_coding
  ENSMUST00000117872 Fgfr2-002 130162512-130266245 protein_coding
  ENSMUST00000118296 Fgfr2-018 130163959-130261857 protein_coding
  ENSMUST00000119260 Fgfr2-011 130163959-130261857 protein_coding
  ENSMUST00000120141 Fgfr2-015 130163959-130261857 protein_coding
  ENSMUST00000120187 Fgfr2-003 130163709-130266263 protein_coding
  ENSMUST00000120715 Fgfr2-010 130163959-130261857 protein_coding
  ENSMUST00000121064 Fgfr2-008 130163959-130261857 protein_coding
  ENSMUST00000121080 Fgfr2-019 130163959-130261857 protein_coding
  ENSMUST00000122054 Fgfr2-004 130163709-130266191 protein_coding
  ENSMUST00000122448 Fgfr2-017 130163959-130261857 protein_coding
  ENSMUST00000124096 Fgfr2-007 130162451-133123350 protein_coding
  ENSMUST00000127091 Fgfr2-021 130199807-130228756 nonsense_mediated_decay
  ENSMUST00000129103 Fgfr2-005 130241029-130263975 retained_intron
  ENSMUST00000129542 Fgfr2-025 130169742-130178064 retained_intron
  ENSMUST00000130557 Fgfr2-027 130163608-130167884 retained_intron
  ENSMUST00000133806 Fgfr2-022 130180471-130196845 retained_intron
  ENSMUST00000136264 Fgfr2-026 130163808-130171914 retained_intron
  ENSMUST00000147859 Fgfr2-024 130177780-130182778 retained_intron
  ENSMUST00000148675 Fgfr2-023 130184911-130196357 retained_intron
  ENSMUST00000153166 Fgfr2-001 130162512-130266245 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonLiverLungOvaryPlacentaENSMUST00000117872ENSMUST00000119260ENSMUST00000120141ENSMUST00000120187ENSMUST00000122054ENSMUST00000124096ENSMUST00000130557ENSMUST00000153166
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Liver Lung Ovary Placenta
ENSMUST00000117872 8.585±4.61 11.104±1.60 9.549±0.78 4.891±1.79 5.089±0.00 5.710±0.86 2.500±1.17 7.626±0.36 10.750±3.29 3.250±0.09
ENSMUST00000119260 N/A N/A N/A 4.437±0.00 N/A N/A N/A N/A N/A N/A
ENSMUST00000120141 N/A N/A N/A N/A N/A N/A N/A N/A 11.500±0.00 14.851±2.67
ENSMUST00000120187 N/A 11.047±1.94 N/A N/A 8.863±1.95 7.950±1.55 1.892±0.21 16.072±3.16 8.250±0.93 9.192±0.00
ENSMUST00000122054 N/A N/A N/A 3.314±0.00 N/A N/A N/A N/A 8.791±0.00 8.264±1.46
ENSMUST00000124096 N/A N/A 11.848±2.11 N/A 12.555±2.69 N/A 3.400±0.80 19.462±2.24 15.958±3.49 6.018±0.00
ENSMUST00000130557 N/A N/A N/A N/A 18.360±0.00 N/A N/A N/A N/A N/A
ENSMUST00000153166 N/A 8.777±0.25 5.327±0.00 N/A 4.171±0.00 5.548±0.58 1.918±0.64 13.417±2.71 8.478±0.71 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002WI CIL_0002WI_0002 CGP 7:129591863-133123350
CIL_0007TN CIL_0007TN_0002 VISTA 7:129759548-130361335
CIL_00095T CIL_00095T_0002 VISTA 7:130125765-130727321
CIL_0001BE CIL_0001BE_0002 CGP 7:130162451-133123350

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001525 IGI angiogenesis
GO:0001657 IGI ureteric bud development
GO:0001701 IGI in utero embryonic development
GO:0001837 IEA epithelial to mesenchymal transition
GO:0002053 IGI positive regulation of mesenchymal cell proliferation
GO:0003148 IMP outflow tract septum morphogenesis
GO:0003149 IMP membranous septum morphogenesis
GO:0005007 IEA fibroblast growth factor-activated receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005576 TAS extracellular region
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0005887 IEA integral component of plasma membrane
GO:0005938 IEA cell cortex
GO:0007267 IMP cell-cell signaling
GO:0007409 IMP axonogenesis
GO:0007528 IMP neuromuscular junction development
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IGI negative regulation of cell proliferation
GO:0008543 IGI fibroblast growth factor receptor signaling pathway
GO:0008589 IMP regulation of smoothened signaling pathway
GO:0009791 IMP post-embryonic development
GO:0009880 IMP embryonic pattern specification
GO:0009887 IMP organ morphogenesis
GO:0009986 IEA cell surface
GO:0010453 IMP regulation of cell fate commitment
GO:0010518 IEA positive regulation of phospholipase activity
GO:0016021 IEA integral component of membrane
GO:0016331 IMP morphogenesis of embryonic epithelium
GO:0017134 IDA fibroblast growth factor binding
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0022612 IMP gland morphogenesis
GO:0030177 IMP positive regulation of Wnt signaling pathway
GO:0030282 IMP bone mineralization
GO:0030324 IMP lung development
GO:0030855 IMP epithelial cell differentiation
GO:0030901 IGI midbrain development
GO:0030916 IMP otic vesicle formation
GO:0031012 IEA extracellular matrix
GO:0031069 IMP hair follicle morphogenesis
GO:0032808 IMP lacrimal gland development
GO:0035264 IMP multicellular organism growth
GO:0035265 IMP organ growth
GO:0040014 IMP regulation of multicellular organism growth
GO:0040036 IMP regulation of fibroblast growth factor receptor signaling pathway
GO:0042127 IMP regulation of cell proliferation
GO:0042472 IMP inner ear morphogenesis
GO:0042476 IMP odontogenesis
GO:0042803 IEA protein homodimerization activity
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043410 IEA positive regulation of MAPK cascade
GO:0045165 IDA cell fate commitment
GO:0045839 IGI negative regulation of mitosis
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046777 IEA protein autophosphorylation
GO:0048286 IGI lung alveolus development
GO:0048333 IEA mesodermal cell differentiation
GO:0048489 IMP synaptic vesicle transport
GO:0048557 IMP embryonic digestive tract morphogenesis
GO:0048562 IMP embryonic organ morphogenesis
GO:0048565 IMP digestive tract development
GO:0048568 IMP embryonic organ development
GO:0048608 IMP reproductive structure development
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0048730 IMP epidermis morphogenesis
GO:0048755 IMP branching morphogenesis of a nerve
GO:0048762 IGI mesenchymal cell differentiation
GO:0050673 IMP epithelial cell proliferation
GO:0050678 IMP regulation of epithelial cell proliferation
GO:0050679 IGI positive regulation of epithelial cell proliferation
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0051150 IMP regulation of smooth muscle cell differentiation
GO:0051781 IMP positive regulation of cell division
GO:0055010 IMP ventricular cardiac muscle tissue morphogenesis
GO:0060045 IGI positive regulation of cardiac muscle cell proliferation
GO:0060174 IMP limb bud formation
GO:0060348 IMP bone development
GO:0060349 IMP bone morphogenesis
GO:0060365 IMP coronal suture morphogenesis
GO:0060441 IMP epithelial tube branching involved in lung morphogenesis
GO:0060442 IMP branching involved in prostate gland morphogenesis
GO:0060445 IMP branching involved in salivary gland morphogenesis
GO:0060449 IMP bud elongation involved in lung branching
GO:0060463 IMP lung lobe morphogenesis
GO:0060484 IMP lung-associated mesenchyme development
GO:0060501 IMP positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060512 IMP prostate gland morphogenesis
GO:0060523 IMP prostate epithelial cord elongation
GO:0060527 IMP prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060529 IMP squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0060595 IMP fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060601 IMP lateral sprouting from an epithelium
GO:0060615 IMP mammary gland bud formation
GO:0060664 IGI epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060667 IGI branch elongation involved in salivary gland morphogenesis
GO:0060670 IMP branching involved in labyrinthine layer morphogenesis
GO:0060687 IMP regulation of branching involved in prostate gland morphogenesis
GO:0060688 IMP regulation of morphogenesis of a branching structure
GO:0060915 IGI mesenchymal cell differentiation involved in lung development
GO:0060916 IMP mesenchymal cell proliferation involved in lung development
GO:0061031 IMP endodermal digestive tract morphogenesis
GO:0070307 IGI lens fiber cell development
GO:0070372 IMP regulation of ERK1 and ERK2 cascade
GO:0070374 IGI positive regulation of ERK1 and ERK2 cascade
GO:0090263 IMP positive regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058115 fgfr2 fibroblast growth factor receptor 2 protein_coding Danio_rerio
ENSG00000066468 FGFR2 fibroblast growth factor receptor 2 protein_coding Homo_sapiens

Loading