C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: inhibitor of kappaB kinase beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031537 Ikbkb 10090 - 8:22659212-22706589 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033939 Ikbkb-001 22659212-22706578 protein_coding
  ENSMUST00000063401 Ikbkb-011 22659768-22706589 protein_coding
  ENSMUST00000125314 Ikbkb-002 22659213-22706540 nonsense_mediated_decay
  ENSMUST00000126439 Ikbkb-006 22691840-22706574 retained_intron
  ENSMUST00000126496 Ikbkb-013 22668011-22669026 retained_intron
  ENSMUST00000131767 Ikbkb-014 22682757-22694065 protein_coding
  ENSMUST00000132279 Ikbkb-012 22660108-22661482 protein_coding
  ENSMUST00000135326 Ikbkb-003 22659213-22706534 nonsense_mediated_decay
  ENSMUST00000144583 Ikbkb-008 22681212-22706539 retained_intron
  ENSMUST00000144895 Ikbkb-007 22689131-22706559 retained_intron
  ENSMUST00000146212 Ikbkb-010 22660357-22706578 retained_intron
  ENSMUST00000149093 Ikbkb-005 22702008-22706563 retained_intron
  ENSMUST00000150214 Ikbkb-004 22702452-22706525 processed_transcript
  ENSMUST00000150259 Ikbkb-009 22675984-22706540 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033939ENSMUST00000063401ENSMUST00000125314ENSMUST00000132279ENSMUST00000135326ENSMUST00000146212
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033939 4.510±2.60 5.815±1.91 8.442±0.73 5.296±1.08 4.804±1.33 6.734±1.41 2.782±0.57 8.575±1.08 5.945±1.92 6.466±0.43 2.897±0.52 6.031±3.10 5.214±2.62 2.119±0.67
ENSMUST00000063401 2.054±0.53 1.748±0.64 N/A 3.413±1.30 3.392±0.89 2.180±0.34 1.028±0.04 1.881±0.29 1.538±0.32 2.915±0.40 N/A 2.173±0.66 N/A 0.988±0.15
ENSMUST00000125314 1.999±0.72 N/A N/A N/A 2.678±0.00 N/A N/A N/A N/A N/A 0.869±0.00 3.431±0.80 N/A 1.709±0.00
ENSMUST00000132279 N/A 9.438±0.80 N/A N/A N/A 12.663±0.00 N/A N/A N/A N/A N/A 10.604±0.00 N/A N/A
ENSMUST00000135326 N/A N/A N/A 1.909±0.33 2.430±0.00 N/A N/A N/A 1.174±0.00 N/A N/A 2.279±0.55 1.150±0.20 N/A
ENSMUST00000146212 N/A 1.709±0.73 1.645±0.00 2.034±0.52 3.011±0.00 1.899±0.31 0.714±0.00 1.693±0.16 1.485±0.14 N/A 0.679±0.23 2.741±1.13 1.906±0.71 0.590±0.12

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001782 IMP B cell homeostasis
GO:0004672 IMP protein kinase activity
GO:0004702 TAS receptor signaling protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 TAS cytoplasm
GO:0007252 TAS I-kappaB phosphorylation
GO:0008384 IDA IkappaB kinase activity
GO:0009898 IDA cytoplasmic side of plasma membrane
GO:0010765 IGI positive regulation of sodium ion transport
GO:0019901 IEA protein kinase binding
GO:0023014 TAS signal transduction by phosphorylation
GO:0035631 IDA CD40 receptor complex
GO:0042501 IEA serine phosphorylation of STAT protein
GO:0042803 IEA protein homodimerization activity
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0051092 ISO positive regulation of NF-kappaB transcription factor activity
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0097110 ISO scaffold protein binding
GO:2001259 IGI positive regulation of cation channel activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079123 ikbkb inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta protein_coding Danio_rerio
ENSG00000104365 IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta protein_coding Homo_sapiens

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