C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dihydroorotate dehydrogenase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031730 Dhodh 10090 - 8:109591343-109608673 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000069058 Dhodh-201 109593248-109608673 protein_coding
  ENSMUST00000123605 Dhodh-001 109593477-109608623 protein_coding
  ENSMUST00000124138 Dhodh-010 109593973-109594950 retained_intron
  ENSMUST00000125222 Dhodh-011 109593247-109594051 processed_transcript
  ENSMUST00000125779 Dhodh-008 109594046-109601511 retained_intron
  ENSMUST00000128350 Dhodh-006 109603303-109608673 protein_coding
  ENSMUST00000131107 Dhodh-003 109601331-109608420 retained_intron
  ENSMUST00000133353 Dhodh-005 109591343-109606232 nonsense_mediated_decay
  ENSMUST00000142106 Dhodh-009 109593901-109596282 retained_intron
  ENSMUST00000143900 Dhodh-002 109593747-109608623 protein_coding
  ENSMUST00000146064 Dhodh-004 109601318-109608420 retained_intron
  ENSMUST00000150804 Dhodh-007 109596030-109608366 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000069058ENSMUST00000123605ENSMUST00000125779ENSMUST00000128350ENSMUST00000131107ENSMUST00000133353ENSMUST00000142106ENSMUST00000146064
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000069058 1.683±0.28 1.950±0.55 1.254±0.31 N/A N/A 1.200±0.25 N/A 1.455±0.11 1.156±0.32 1.667±0.12 1.007±0.00 2.174±0.32 0.723±0.00 0.437±0.00
ENSMUST00000123605 3.313±0.30 2.298±0.85 4.182±0.90 3.075±1.73 3.090±1.41 1.655±0.68 3.644±0.16 3.079±0.73 3.123±1.94 2.119±0.21 5.761±0.76 3.659±0.66 3.640±3.17 0.963±0.22
ENSMUST00000125779 6.499±0.72 6.995±1.95 4.413±1.47 7.763±3.49 8.095±1.69 4.785±1.16 4.788±1.70 4.675±1.39 6.252±2.68 5.983±0.90 N/A 11.894±4.91 6.807±3.74 1.930±0.14
ENSMUST00000128350 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.660±0.00 4.108±2.56 1.302±0.00
ENSMUST00000131107 N/A N/A N/A N/A 0.916±0.00 1.367±0.00 N/A N/A N/A 1.222±0.01 N/A N/A N/A 0.485±0.00
ENSMUST00000133353 N/A N/A N/A 0.422±0.00 N/A N/A N/A 0.531±0.00 0.486±0.07 N/A N/A N/A 0.322±0.00 N/A
ENSMUST00000142106 5.179±0.42 4.518±0.87 2.629±0.00 2.527±0.00 5.966±0.56 3.149±0.73 3.425±1.11 4.312±0.89 3.296±0.95 N/A N/A 10.394±3.96 2.900±1.13 1.608±0.29
ENSMUST00000146064 N/A 9.178±2.57 N/A 3.332±0.00 7.205±0.00 3.737±0.51 N/A N/A 2.104±0.00 N/A N/A 8.884±0.81 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008FG CIL_0008FG_0002 VISTA 8:109010589-109613918
CIL_00098B CIL_00098B_0002 VISTA 8:109116597-109718209
CIL_00098E CIL_00098E_0002 VISTA 8:109136455-109737561

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004152 IEA dihydroorotate dehydrogenase activity
GO:0005739 IDA mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0006207 IEA 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006222 IEA UMP biosynthetic process
GO:0007565 IEA female pregnancy
GO:0007595 IEA lactation
GO:0008144 IEA drug binding
GO:0010181 IEA FMN binding
GO:0014070 IEA response to organic cyclic compound
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0031000 IEA response to caffeine
GO:0042493 IEA response to drug
GO:0042594 IEA response to starvation
GO:0043025 IEA neuronal cell body
GO:0043065 IEA positive regulation of apoptotic process
GO:0044205 IEA 'de novo' UMP biosynthetic process
GO:0048039 IEA ubiquinone binding
GO:0055114 IEA oxidation-reduction process
GO:0090140 IEA regulation of mitochondrial fission

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000051889 dhodh dihydroorotate dehydrogenase protein_coding Danio_rerio
ENSG00000102967 DHODH dihydroorotate dehydrogenase (quinone) protein_coding Homo_sapiens

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