C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NK6 homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000035187 Nkx6-1 10090 - 5:101659177-101664996 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000044125 Nkx6-1-001 101659177-101664996 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000044125
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000044125 0.025±0.00 0.013±0.00 0.088±0.02 0.535±0.42 0.063±0.03 0.011±0.00 0.051±0.02 0.056±0.03 0.019±0.01 0.173±0.12 0.057±0.00 0.028±0.01 0.197±0.26 0.236±0.11

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006J7 CIL_0006J7_0002 CGP 5:100845713-101664996
CIL_0007QY CIL_0007QY_0002 VISTA 5:101196956-101797906
CIL_0006J6 CIL_0006J6_0002 CGP 5:101659177-101823858

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003323 IEA type B pancreatic cell development
GO:0003682 IEA chromatin binding
GO:0003700 TAS sequence-specific DNA binding transcription factor activity
GO:0005634 IDA nucleus
GO:0005829 TAS cytosol
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007224 IDA smoothened signaling pathway
GO:0008283 IEA cell proliferation
GO:0021912 IGI regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
GO:0021913 IMP regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
GO:0021953 IMP central nervous system neuron differentiation
GO:0022008 IEA neurogenesis
GO:0030154 IGI cell differentiation
GO:0030516 IMP regulation of axon extension
GO:0031018 IGI endocrine pancreas development
GO:0032024 IEA positive regulation of insulin secretion
GO:0035094 IEA response to nicotine
GO:0042493 IEA response to drug
GO:0043565 IEA sequence-specific DNA binding
GO:0045666 IDA positive regulation of neuron differentiation
GO:0045686 IGI negative regulation of glial cell differentiation
GO:0045687 IGI positive regulation of glial cell differentiation
GO:0048709 IGI oligodendrocyte differentiation
GO:0070062 IEA extracellular vesicular exosome
GO:0071345 IEA cellular response to cytokine stimulus
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:2001222 IMP regulation of neuron migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022569 nkx6.1 NK6 homeobox 1 protein_coding Danio_rerio
ENSG00000163623 NKX6-1 NK6 homeobox 1 protein_coding Homo_sapiens

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