C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NK6 homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000163623 NKX6-1 9606 - 4:84491987-84498450 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000295886 NKX6-1-001 84491987-84498450 protein_coding
  ENST00000515820 NKX6-1-002 84491987-84496950 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000295886ENST00000515820
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000295886 0.008±0.00 0.024±0.00 0.081±0.00 0.289±0.00 0.023±0.00 0.007±0.00 0.008±0.00 0.008±0.00 0.102±0.00 0.006±0.00 0.396±0.39 0.125±0.11 0.614±0.18
ENST00000515820 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.001±0.00 0.171±0.00 0.019±0.00 0.148±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006J7 CIL_0006J7_0001 CGP 4:83535914-84498450
CIL_0007QY CIL_0007QY_0001 VISTA 4:84024438-84625402
CIL_0006J6 CIL_0006J6_0001 CGP 4:84491987-84651338

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003323 IEA type B pancreatic cell development
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005634 IEA:IDA nucleus
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007224 IEA smoothened signaling pathway
GO:0008283 IEA cell proliferation
GO:0009887 TAS organ morphogenesis
GO:0021912 IEA regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
GO:0021913 IEA regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
GO:0021953 IEA central nervous system neuron differentiation
GO:0022008 IEA neurogenesis
GO:0030154 IEA cell differentiation
GO:0030516 IEA regulation of axon extension
GO:0031016 ISS pancreas development
GO:0031018 TAS endocrine pancreas development
GO:0032024 IEA positive regulation of insulin secretion
GO:0035094 IEA response to nicotine
GO:0042493 IEA response to drug
GO:0043565 IEA sequence-specific DNA binding
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045686 IEA negative regulation of glial cell differentiation
GO:0045687 IEA positive regulation of glial cell differentiation
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0048709 IEA oligodendrocyte differentiation
GO:0051091 ISS positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051594 ISS detection of glucose
GO:0070062 IDA extracellular vesicular exosome
GO:0071345 IEA cellular response to cytokine stimulus
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0072560 ISS type B pancreatic cell maturation
GO:2000078 ISS positive regulation of type B pancreatic cell development
GO:2001222 IEA regulation of neuron migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022569 nkx6.1 NK6 homeobox 1 protein_coding Danio_rerio
ENSMUSG00000035187 Nkx6-1 NK6 homeobox 1 protein_coding Mus_musculus

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