C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: apurinic/apyrimidinic endonuclease 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000035960 Apex1 10090 + 14:50924968-50927139 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000049411 Apex1-001 50924968-50927139 protein_coding
  ENSMUST00000128395 Apex1-003 50925285-50927139 protein_coding
  ENSMUST00000136753 Apex1-004 50924969-50926551 protein_coding
  ENSMUST00000154288 Apex1-002 50924978-50925608 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainLiverMuscleOvaryPlacentaTestisENSMUST00000049411ENSMUST00000136753
Transcript ID Brain Liver Muscle Ovary Placenta Testis
ENSMUST00000049411 N/A 19.050±8.67 4.624±1.46 N/A 19.707±0.00 N/A
ENSMUST00000136753 28.471±0.00 N/A 7.637±1.34 39.766±3.38 45.680±2.92 16.631±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004Z3 CIL_0004Z3_0003 CGP 14:50906478-50927139
CIL_0001O8 CIL_0001O8_0002 CGP 14:50924968-50930856

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000737 IBA:IEA DNA catabolic process, endonucleolytic
GO:0000738 IBA DNA catabolic process, exonucleolytic
GO:0003677 ISS DNA binding
GO:0003684 ISS damaged DNA binding
GO:0003713 ISS transcription coactivator activity
GO:0003906 IBA:ISS DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004519 IEA endonuclease activity
GO:0004521 IEA endoribonuclease activity
GO:0005515 IEA protein binding
GO:0005634 IDA:ISS nucleus
GO:0005654 ISS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005730 ISS nucleolus
GO:0005737 IDA cytoplasm
GO:0005739 ISS mitochondrion
GO:0005783 IEA endoplasmic reticulum
GO:0005813 IEA centrosome
GO:0006281 ISS DNA repair
GO:0006284 IBA base-excision repair
GO:0006310 IEA DNA recombination
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007568 IEA aging
GO:0008081 IEA phosphoric diester hydrolase activity
GO:0008311 IBA double-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008408 ISS 3'-5' exonuclease activity
GO:0010243 IEA response to organonitrogen compound
GO:0014912 IEA negative regulation of smooth muscle cell migration
GO:0016491 ISS oxidoreductase activity
GO:0016607 ISS nuclear speck
GO:0016890 ISS site-specific endodeoxyribonuclease activity, specific for altered base
GO:0031490 ISS chromatin DNA binding
GO:0032403 IEA protein complex binding
GO:0042493 IEA response to drug
GO:0043488 ISS regulation of mRNA stability
GO:0044822 IEA poly(A) RNA binding
GO:0045454 IDA cell redox homeostasis
GO:0045739 ISS positive regulation of DNA repair
GO:0046872 ISS metal ion binding
GO:0048471 ISS perinuclear region of cytoplasm
GO:0051059 IEA NF-kappaB binding
GO:0055114 IEA oxidation-reduction process
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071320 IEA cellular response to cAMP
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071417 IEA cellular response to organonitrogen compound
GO:0080111 ISS DNA demethylation
GO:0090305 ISS nucleic acid phosphodiester bond hydrolysis
GO:0090502 IEA RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900087 IEA positive regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045843 apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 protein_coding Danio_rerio
ENSG00000100823 APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 protein_coding Homo_sapiens

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