C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: apurinic/apyrimidinic endonuclease 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000049411 Apex1-001 ENSMUSG00000035960 10090 + 14:50924968-50927139 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; LiverMusclePlacentaENSMUST00000049411
Transcript ID Liver Muscle Placenta
ENSMUST00000049411 19.050±8.67 4.624±1.46 19.707±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004Z3 CIL_0004Z3_0003 CGP 14:50906478-50927139
CIL_0001O8 CIL_0001O8_0002 CGP 14:50924968-50930856

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000737 IBA:IEA DNA catabolic process, endonucleolytic
GO:0000738 IBA DNA catabolic process, exonucleolytic
GO:0003677 ISS DNA binding
GO:0003684 ISS damaged DNA binding
GO:0003713 ISS transcription coactivator activity
GO:0003906 IBA:ISS DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004519 IEA endonuclease activity
GO:0004521 IEA endoribonuclease activity
GO:0005515 IEA protein binding
GO:0005634 IDA:ISS nucleus
GO:0005654 ISS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005730 ISS nucleolus
GO:0005737 IDA cytoplasm
GO:0005739 ISS mitochondrion
GO:0005783 IEA endoplasmic reticulum
GO:0005813 IEA centrosome
GO:0006281 ISS DNA repair
GO:0006284 IBA base-excision repair
GO:0006310 IEA DNA recombination
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007568 IEA aging
GO:0008081 IEA phosphoric diester hydrolase activity
GO:0008311 IBA double-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008408 ISS 3'-5' exonuclease activity
GO:0010243 IEA response to organonitrogen compound
GO:0014912 IEA negative regulation of smooth muscle cell migration
GO:0016491 ISS oxidoreductase activity
GO:0016607 ISS nuclear speck
GO:0016890 ISS site-specific endodeoxyribonuclease activity, specific for altered base
GO:0031490 ISS chromatin DNA binding
GO:0032403 IEA protein complex binding
GO:0042493 IEA response to drug
GO:0043488 ISS regulation of mRNA stability
GO:0044822 IEA poly(A) RNA binding
GO:0045454 IDA cell redox homeostasis
GO:0045739 ISS positive regulation of DNA repair
GO:0046872 ISS metal ion binding
GO:0048471 ISS perinuclear region of cytoplasm
GO:0051059 IEA NF-kappaB binding
GO:0055114 IEA oxidation-reduction process
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071320 IEA cellular response to cAMP
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071417 IEA cellular response to organonitrogen compound
GO:0080111 ISS DNA demethylation
GO:0090305 ISS nucleic acid phosphodiester bond hydrolysis
GO:0090502 IEA RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900087 IEA positive regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000216714 APEX1-001 protein_coding Homo_sapiens 0 1072
ENST00000398030 APEX1-008 protein_coding Homo_sapiens 0 1072
ENST00000438886 APEX1-003 protein_coding Homo_sapiens 0 363
ENST00000553368 APEX1-019 protein_coding Homo_sapiens 1e-31 139
ENST00000553555 APEX1-007 retained_intron Homo_sapiens 0 1072
ENST00000553681 APEX1-009 protein_coding Homo_sapiens 0 852
ENST00000554325 APEX1-015 nonsense_mediated_decay Homo_sapiens 0 268
ENST00000554813 APEX1-010 processed_transcript Homo_sapiens 0 623
ENST00000555306 APEX1-012 retained_intron Homo_sapiens 0 464
ENST00000555414 APEX1-002 protein_coding Homo_sapiens 0 1072
ENST00000555839 APEX1-016 protein_coding Homo_sapiens 0 492
ENST00000556054 APEX1-017 protein_coding Homo_sapiens 0 584
ENST00000557054 APEX1-006 protein_coding Homo_sapiens 0 435
ENST00000557150 APEX1-021 protein_coding Homo_sapiens 0 573
ENST00000557159 APEX1-005 retained_intron Homo_sapiens 0 1044
ENST00000557181 APEX1-014 protein_coding Homo_sapiens 0 359
ENST00000557344 APEX1-013 protein_coding Homo_sapiens 0 486
ENST00000557365 APEX1-020 processed_transcript Homo_sapiens 0 793
ENST00000557592 APEX1-018 protein_coding Homo_sapiens 0 606

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