C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: APEX nuclease (multifunctional DNA repair enzyme) 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100823 APEX1 9606 + 14:20455191-20457772 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000216714 APEX1-001 20455195-20457767 protein_coding
  ENST00000398030 APEX1-008 20455226-20457767 protein_coding
  ENST00000438886 APEX1-003 20456007-20457222 protein_coding
  ENST00000553368 APEX1-019 20455245-20456031 protein_coding
  ENST00000553555 APEX1-007 20455226-20457734 retained_intron
  ENST00000553681 APEX1-009 20455201-20457342 protein_coding
  ENST00000554325 APEX1-015 20455227-20456683 nonsense_mediated_decay
  ENST00000554813 APEX1-010 20455215-20457139 processed_transcript
  ENST00000555306 APEX1-012 20455226-20457002 retained_intron
  ENST00000555414 APEX1-002 20455191-20457772 protein_coding
  ENST00000555839 APEX1-016 20455239-20457366 protein_coding
  ENST00000556054 APEX1-017 20455247-20457074 protein_coding
  ENST00000556296 APEX1-011 20455219-20455887 processed_transcript
  ENST00000557054 APEX1-006 20455247-20457767 protein_coding
  ENST00000557150 APEX1-021 20455265-20457089 protein_coding
  ENST00000557159 APEX1-005 20455240-20457738 retained_intron
  ENST00000557181 APEX1-014 20455227-20456744 protein_coding
  ENST00000557344 APEX1-013 20455226-20456860 protein_coding
  ENST00000557365 APEX1-020 20455257-20457302 processed_transcript
  ENST00000557592 APEX1-018 20455248-20457119 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000216714ENST00000398030ENST00000553555ENST00000553681ENST00000555306ENST00000555414ENST00000555839ENST00000556296ENST00000557054ENST00000557159ENST00000557344
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000216714 N/A N/A 4.755±0.00 12.344±0.00 8.824±0.00 7.864±0.00 2.497±0.00 5.656±0.00 10.019±0.00 3.961±0.00 2.503±0.00 30.476±16.13 34.541±10.18 7.153±0.00
ENST00000398030 26.355±0.00 35.831±0.00 N/A 24.998±0.00 42.020±0.00 12.800±7.60 7.996±0.00 26.944±0.00 19.313±0.00 6.723±4.73 19.747±0.00 64.068±0.00 N/A 22.724±0.00
ENST00000553555 N/A N/A N/A N/A N/A N/A 4.913±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000553681 37.554±0.00 64.871±0.00 N/A 51.818±0.00 71.121±0.00 37.303±0.00 16.519±0.00 47.256±0.00 15.089±0.00 19.626±0.00 26.088±0.00 63.829±0.00 N/A 37.996±0.00
ENST00000555306 N/A N/A N/A N/A N/A N/A N/A 4.425±0.00 N/A N/A N/A 18.136±0.00 N/A 8.222±0.00
ENST00000555414 N/A N/A N/A N/A N/A N/A N/A 6.828±0.00 N/A 8.034±0.00 1.716±0.00 33.894±31.65 23.739±2.05 N/A
ENST00000555839 23.254±0.00 N/A N/A N/A N/A 20.225±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000556296 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.186±0.00 N/A N/A N/A
ENST00000557054 N/A N/A N/A N/A N/A N/A 13.095±0.00 N/A 12.221±1.94 15.187±0.00 20.762±0.00 N/A N/A N/A
ENST00000557159 N/A 19.152±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000557344 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 20.596±0.00 44.743±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004Z3 CIL_0004Z3_0002 CGP 14:20446411-20457772
CIL_0001O8 CIL_0001O8_0001 CGP 14:20455191-20461612

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000737 IEA DNA catabolic process, endonucleolytic
GO:0000738 IBA DNA catabolic process, exonucleolytic
GO:0003677 IEA:IDA DNA binding
GO:0003684 IDA damaged DNA binding
GO:0003713 IDA transcription coactivator activity
GO:0003714 TAS transcription corepressor activity
GO:0003906 IDA DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004518 IEA nuclease activity
GO:0004519 IDA endonuclease activity
GO:0004520 TAS endodeoxyribonuclease activity
GO:0004521 IEA endoribonuclease activity
GO:0004523 TAS RNA-DNA hybrid ribonuclease activity
GO:0004528 TAS phosphodiesterase I activity
GO:0004844 TAS uracil DNA N-glycosylase activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005783 TAS endoplasmic reticulum
GO:0005813 IDA centrosome
GO:0005840 TAS ribosome
GO:0006281 IEA:IDA DNA repair
GO:0006284 IBA base-excision repair
GO:0006310 IEA DNA recombination
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007568 IEA aging
GO:0008081 IDA phosphoric diester hydrolase activity
GO:0008311 IBA double-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008408 TAS 3'-5' exonuclease activity
GO:0010243 IEA response to organonitrogen compound
GO:0014912 IEA negative regulation of smooth muscle cell migration
GO:0016491 IDA oxidoreductase activity
GO:0016607 IDA nuclear speck
GO:0016890 IDA site-specific endodeoxyribonuclease activity, specific for altered base
GO:0031490 IDA chromatin DNA binding
GO:0032403 IEA protein complex binding
GO:0042493 IEA response to drug
GO:0043488 IMP regulation of mRNA stability
GO:0044822 IDA poly(A) RNA binding
GO:0045454 IEA cell redox homeostasis
GO:0045739 IDA positive regulation of DNA repair
GO:0046872 IDA metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051059 IEA NF-kappaB binding
GO:0055114 IDA oxidation-reduction process
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071320 IEA cellular response to cAMP
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071417 IEA cellular response to organonitrogen compound
GO:0080111 IDA DNA demethylation
GO:0090305 TAS nucleic acid phosphodiester bond hydrolysis
GO:0090502 TAS RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900087 IEA positive regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045843 apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 protein_coding Danio_rerio
ENSMUSG00000035960 Apex1 apurinic/apyrimidinic endonuclease 1 protein_coding Mus_musculus

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