C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: leucine-rich repeat kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000036273 Lrrk2 10090 + 15:91673175-91816120 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000060642 Lrrk2-001 91673175-91816120 protein_coding
  ENSMUST00000133743 Lrrk2-003 91780378-91816026 processed_transcript
  ENSMUST00000137657 Lrrk2-004 91808238-91816026 retained_intron
  ENSMUST00000140734 Lrrk2-002 91738948-91789110 processed_transcript
  ENSMUST00000156900 Lrrk2-005 91772345-91778491 processed_transcript
  ENSMUST00000172797 Lrrk2-006 91814628-91816119 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000060642ENSMUST00000133743ENSMUST00000137657ENSMUST00000140734ENSMUST00000156900
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000060642 1.144±0.75 2.597±1.53 2.010±0.22 1.357±1.60 1.743±0.44 0.434±0.17 1.323±0.19 7.598±2.13 0.340±0.30 3.900±1.61 0.556±0.18 1.647±1.28 0.432±0.21 0.509±0.09
ENSMUST00000133743 N/A N/A N/A 2.214±0.00 N/A N/A N/A N/A 0.230±0.02 N/A N/A N/A 0.329±0.00 2.566±0.46
ENSMUST00000137657 N/A N/A N/A 0.148±0.01 1.219±0.34 0.582±0.06 N/A N/A 0.276±0.12 2.973±0.09 N/A 0.891±0.27 N/A 0.381±0.00
ENSMUST00000140734 N/A N/A N/A N/A N/A 0.417±0.00 N/A N/A 0.102±0.03 N/A N/A 0.640±0.00 0.375±0.00 N/A
ENSMUST00000156900 N/A N/A N/A 22.249±0.00 N/A N/A N/A N/A N/A N/A N/A 16.294±0.00 2.367±0.00 10.420±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006R2 CIL_0006R2_0002 CGP 15:91267696-91816120

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000149 IEA SNARE binding
GO:0000165 IEA MAPK cascade
GO:0000186 IEA activation of MAPKK activity
GO:0000187 IEA activation of MAPK activity
GO:0001933 IMP negative regulation of protein phosphorylation
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0001948 IEA glycoprotein binding
GO:0003779 IEA actin binding
GO:0003924 IEA GTPase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0005096 IEA GTPase activator activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005525 ISA GTP binding
GO:0005615 IEA extracellular space
GO:0005737 IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005741 IDA mitochondrial outer membrane
GO:0005743 IDA mitochondrial inner membrane
GO:0005759 IDA mitochondrial matrix
GO:0005764 IDA lysosome
GO:0005768 IDA endosome
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0005829 IEA cytosol
GO:0005886 IDA plasma membrane
GO:0006184 IEA GTP catabolic process
GO:0006468 ISA protein phosphorylation
GO:0006897 IEA endocytosis
GO:0006914 IEA autophagy
GO:0006979 IEA response to oxidative stress
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007528 IEA neuromuscular junction development
GO:0008021 IDA synaptic vesicle
GO:0008340 IEA determination of adult lifespan
GO:0010508 IMP positive regulation of autophagy
GO:0010738 IMP regulation of protein kinase A signaling
GO:0010955 IEA negative regulation of protein processing
GO:0014041 IEA regulation of neuron maturation
GO:0015631 IEA tubulin binding
GO:0016020 IEA membrane
GO:0016234 IEA inclusion body
GO:0016301 ISS kinase activity
GO:0017048 IPI Rho GTPase binding
GO:0017075 IEA syntaxin-1 binding
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0021772 IEA olfactory bulb development
GO:0022028 IEA tangential migration from the subventricular zone to the olfactory bulb
GO:0030276 IEA clathrin binding
GO:0030424 ISS axon
GO:0030425 IDA dendrite
GO:0031398 IEA positive regulation of protein ubiquitination
GO:0031410 IDA cytoplasmic vesicle
GO:0031966 IEA mitochondrial membrane
GO:0032091 IEA negative regulation of protein binding
GO:0032092 IEA positive regulation of protein binding
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032473 IEA cytoplasmic side of mitochondrial outer membrane
GO:0032839 IEA dendrite cytoplasm
GO:0034211 ISA GTP-dependent protein kinase activity
GO:0034260 ISO negative regulation of GTPase activity
GO:0034599 IEA cellular response to oxidative stress
GO:0034613 IMP cellular protein localization
GO:0035556 IMP intracellular signal transduction
GO:0035564 IMP regulation of kidney size
GO:0035640 IEA exploration behavior
GO:0035641 IMP locomotory exploration behavior
GO:0036465 TAS synaptic vesicle recycling
GO:0036479 IEA peroxidase inhibitor activity
GO:0040012 IEA regulation of locomotion
GO:0042391 IEA regulation of membrane potential
GO:0042802 IPI identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0043005 IEA neuron projection
GO:0043025 IEA neuronal cell body
GO:0043068 IEA positive regulation of programmed cell death
GO:0043195 IC terminal bouton
GO:0043204 ISS perikaryon
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043547 IEA positive regulation of GTPase activity
GO:0044325 IEA ion channel binding
GO:0045121 IDA membrane raft
GO:0045202 IDA synapse
GO:0046777 ISA protein autophosphorylation
GO:0048312 IEA intracellular distribution of mitochondria
GO:0048812 ISS neuron projection morphogenesis
GO:0051018 IPI protein kinase A binding
GO:0051900 IEA regulation of mitochondrial depolarization
GO:0051966 IMP regulation of synaptic transmission, glutamatergic
GO:0060079 IMP regulation of excitatory postsynaptic membrane potential
GO:0060159 IMP regulation of dopamine receptor signaling pathway
GO:0060161 IEA positive regulation of dopamine receptor signaling pathway
GO:0061001 IMP regulation of dendritic spine morphogenesis
GO:0070062 IEA extracellular vesicular exosome
GO:0070997 IEA neuron death
GO:0071287 IEA cellular response to manganese ion
GO:0071407 IEA cellular response to organic cyclic compound
GO:0072593 IEA reactive oxygen species metabolic process
GO:1901214 IEA regulation of neuron death
GO:1902499 IEA positive regulation of protein autoubiquitination
GO:1902692 IEA regulation of neuroblast proliferation
GO:1902803 IMP regulation of synaptic vesicle transport
GO:1903125 IEA negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
GO:1903206 IEA negative regulation of hydrogen peroxide-induced cell death
GO:1903215 IEA negative regulation of protein targeting to mitochondrion
GO:1903351 IEA cellular response to dopamine
GO:2000172 IEA regulation of branching morphogenesis of a nerve
GO:2000300 IEA regulation of synaptic vesicle exocytosis
GO:2000469 IEA negative regulation of peroxidase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007398 LRRK1 (1 of 2) leucine-rich repeat kinase 2 protein_coding Danio_rerio
ENSDARG00000089483 LRRK1 (2 of 2) leucine-rich repeat kinase 2 protein_coding Danio_rerio
ENSG00000188906 LRRK2 leucine-rich repeat kinase 2 protein_coding Homo_sapiens

Loading