C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: forkhead box A2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000037025 Foxa2 10090 - 2:148042877-148046969 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000047315 Foxa2-001 148042877-148046969 protein_coding
  ENSMUST00000109964 Foxa2-002 148042877-148045948 protein_coding
  ENSMUST00000146242 Foxa2-003 148044240-148045464 processed_transcript
  ENSMUST00000172928 Foxa2-004 148043542-148046896 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000047315ENSMUST00000109964ENSMUST00000146242ENSMUST00000172928
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000047315 N/A N/A N/A N/A N/A N/A N/A N/A 5.296±3.48 5.452±0.00 N/A 0.703±0.33 1.351±0.00 N/A
ENSMUST00000109964 2.889±1.36 N/A 0.012±0.01 1.140±0.78 0.064±0.05 26.282±7.78 0.090±0.01 0.015±0.00 7.581±5.04 23.797±6.37 N/A 2.236±0.90 4.690±3.98 0.036±0.03
ENSMUST00000146242 N/A 0.060±0.03 0.049±0.00 0.169±0.00 0.040±0.01 N/A N/A N/A N/A N/A N/A N/A N/A 0.026±0.00
ENSMUST00000172928 0.032±0.00 N/A 0.029±0.01 1.840±0.00 N/A N/A N/A 0.069±0.00 2.520±1.75 N/A 0.242±0.00 N/A N/A 0.033±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XI CIL_0002XI_0002 CGP 2:147361925-148046969
CIL_0001U5 CIL_0001U5_0002 CGP 2:148042877-148396767

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000432 IDA positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0000433 IDA negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001205 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001701 IMP in utero embryonic development
GO:0001705 IGI ectoderm formation
GO:0001708 IDA cell fate specification
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007389 IGI pattern specification process
GO:0008134 IEA transcription factor binding
GO:0008344 IMP adult locomotory behavior
GO:0009653 IGI anatomical structure morphogenesis
GO:0009952 IGI anterior/posterior pattern specification
GO:0009953 IGI dorsal/ventral pattern formation
GO:0010468 IGI regulation of gene expression
GO:0010719 IEA negative regulation of epithelial to mesenchymal transition
GO:0016568 IEA chromatin modification
GO:0019216 IDA regulation of lipid metabolic process
GO:0019218 IDA regulation of steroid metabolic process
GO:0019904 IEA protein domain specific binding
GO:0021533 IGI cell differentiation in hindbrain
GO:0021904 IDA dorsal/ventral neural tube patterning
GO:0023019 IDA signal transduction involved in regulation of gene expression
GO:0030193 IEA regulation of blood coagulation
GO:0030324 IGI lung development
GO:0031018 IMP endocrine pancreas development
GO:0032525 IMP somite rostral/caudal axis specification
GO:0033132 IDA negative regulation of glucokinase activity
GO:0040019 IMP positive regulation of embryonic development
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045665 IGI negative regulation of neuron differentiation
GO:0045666 IGI positive regulation of neuron differentiation
GO:0045880 IGI positive regulation of smoothened signaling pathway
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0045945 IMP positive regulation of transcription from RNA polymerase III promoter
GO:0048468 IMP cell development
GO:0048646 IGI anatomical structure formation involved in morphogenesis
GO:0048665 IGI neuron fate specification
GO:0060441 IGI epithelial tube branching involved in lung morphogenesis
GO:0060487 IGI lung epithelial cell differentiation
GO:0061178 IDA regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061448 IGI connective tissue development
GO:0070741 TAS response to interleukin-6
GO:0071542 IMP dopaminergic neuron differentiation
GO:0090009 IMP primitive streak formation
GO:2000543 IMP positive regulation of gastrulation
GO:2000971 IDA negative regulation of detection of glucose
GO:2000976 IDA regulation of transcription from RNA polymerase II promoter involved in detection of glucose

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003411 foxa2 forkhead box A2 protein_coding Danio_rerio
ENSG00000125798 FOXA2 forkhead box A2 protein_coding Homo_sapiens

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