C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: suppressor of cytokine signaling 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000037104 Socs5 10090 + 17:87107679-87137583 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000041369 Socs5-201 87107679-87137583 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000041369
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000041369 1.071±0.05 12.820±1.16 4.501±0.31 5.176±2.52 4.598±0.10 4.867±1.36 6.416±0.00 0.781±0.50 6.261±4.84 1.536±0.85 7.982±3.12 0.474±0.04 0.569±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006KQ CIL_0006KQ_0002 CGP 17:87025550-87137583
CIL_0008D2 CIL_0008D2_0002 VISTA 17:87075116-87678515
CIL_0006KK CIL_0006KK_0002 CGP 17:87107679-87265935

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005154 IPI epidermal growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005737 NAS cytoplasm
GO:0007173 IDA epidermal growth factor receptor signaling pathway
GO:0007175 ISS negative regulation of epidermal growth factor-activated receptor activity
GO:0007259 TAS JAK-STAT cascade
GO:0009968 NAS negative regulation of signal transduction
GO:0016049 NAS cell growth
GO:0016567 IEA protein ubiquitination
GO:0019210 NAS kinase inhibitor activity
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0030971 IEA receptor tyrosine kinase binding
GO:0032436 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0040008 IEA regulation of growth
GO:0045627 IDA positive regulation of T-helper 1 cell differentiation
GO:0045629 IDA negative regulation of T-helper 2 cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061573 socs5a suppressor of cytokine signaling 5a protein_coding Danio_rerio
ENSDARG00000062745 socs5b suppressor of cytokine signaling 5b protein_coding Danio_rerio
ENSG00000171150 SOCS5 suppressor of cytokine signaling 5 protein_coding Homo_sapiens

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