C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: suppressor of cytokine signaling 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171150 SOCS5 9606 + 2:46698952-46763129 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000306503 SOCS5-001 46698952-46763129 protein_coding
  ENST00000394861 SOCS5-002 46699187-46762313 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000306503ENST00000394861
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000306503 N/A 2.366±0.00 N/A 0.616±0.00 2.009±0.10 0.355±0.00 0.790±0.00 0.249±0.00 N/A 1.480±0.00 N/A 2.670±1.45 1.037±0.46 1.413±0.62
ENST00000394861 2.931±0.00 2.772±0.00 0.956±0.00 3.657±0.62 2.440±0.40 3.250±0.10 1.765±0.34 1.009±0.08 2.409±1.74 2.030±0.37 1.483±0.39 3.727±0.89 1.774±0.57 3.987±1.91

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006KQ CIL_0006KQ_0001 CGP 2:46616416-46763129
CIL_0006KK CIL_0006KK_0001 CGP 2:46698952-46941855

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005154 IEA epidermal growth factor receptor binding
GO:0005515 IPI protein binding
GO:0007173 IEA epidermal growth factor receptor signaling pathway
GO:0007175 IDA negative regulation of epidermal growth factor-activated receptor activity
GO:0007259 IEA JAK-STAT cascade
GO:0009968 NAS negative regulation of signal transduction
GO:0016049 NAS cell growth
GO:0016567 IEA protein ubiquitination
GO:0019221 ISS cytokine-mediated signaling pathway
GO:0030971 IPI receptor tyrosine kinase binding
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556 IEA intracellular signal transduction
GO:0040008 IEA regulation of growth
GO:0045627 ISS positive regulation of T-helper 1 cell differentiation
GO:0045629 ISS negative regulation of T-helper 2 cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061573 socs5a suppressor of cytokine signaling 5a protein_coding Danio_rerio
ENSDARG00000062745 socs5b suppressor of cytokine signaling 5b protein_coding Danio_rerio
ENSMUSG00000037104 Socs5 suppressor of cytokine signaling 5 protein_coding Mus_musculus

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