C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: GTP cyclohydrolase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000037580 Gch1 10090 - 14:47153895-47189413 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000089959 Gch1-201 47153895-47189413 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000089959
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000089959 2.219±0.23 67.932±6.73 2.219±0.60 0.804±0.51 3.527±1.33 9.121±3.83 2.752±0.23 1.267±0.20 37.149±34.53 7.295±1.93 0.558±0.08 18.241±8.62 2.623±1.47 0.295±0.20

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000009 CIL_000009_0003 CGP 14:46882854-47189413
CIL_000005 CIL_000005_0003 CGP 14:47153895-47276857

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003934 IDA GTP cyclohydrolase I activity
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005525 IEA GTP binding
GO:0005634 IEA nucleus
GO:0005829 IEA cytosol
GO:0006184 IEA GTP catabolic process
GO:0006461 IEA protein complex assembly
GO:0006729 IC tetrahydrobiopterin biosynthetic process
GO:0008152 IEA metabolic process
GO:0008217 IMP regulation of blood pressure
GO:0008270 IEA zinc ion binding
GO:0014916 IMP regulation of lung blood pressure
GO:0030742 IEA GTP-dependent protein binding
GO:0031410 IEA cytoplasmic vesicle
GO:0031965 IEA nuclear membrane
GO:0032496 IEA response to lipopolysaccharide
GO:0034341 IEA response to interferon-gamma
GO:0034612 IEA response to tumor necrosis factor
GO:0035998 IEA 7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0042311 IEA vasodilation
GO:0042416 IEA dopamine biosynthetic process
GO:0042559 IEA pteridine-containing compound biosynthetic process
GO:0042803 IEA protein homodimerization activity
GO:0043234 IEA protein complex
GO:0045776 IEA negative regulation of blood pressure
GO:0046654 IEA tetrahydrofolate biosynthetic process
GO:0048265 ISS response to pain
GO:0050662 IEA coenzyme binding
GO:0050884 IEA neuromuscular process controlling posture
GO:0051000 IEA positive regulation of nitric-oxide synthase activity
GO:0051066 IEA dihydrobiopterin metabolic process
GO:0051260 IEA protein homooligomerization
GO:0051291 IEA protein heterooligomerization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070453 gch1 GTP cyclohydrolase 1 protein_coding Danio_rerio
ENSG00000131979 GCH1 GTP cyclohydrolase 1 protein_coding Homo_sapiens

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