C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: GTP cyclohydrolase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000131979 GCH1 9606 - 14:54842008-54902852 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000254299 GCH1-001 54842017-54902811 processed_transcript
  ENST00000395514 GCH1-201 54842008-54902824 protein_coding
  ENST00000395521 GCH1-005 54842996-54902446 processed_transcript
  ENST00000491895 GCH1-002 54842016-54902852 protein_coding
  ENST00000536224 GCH1-004 54842029-54902816 protein_coding
  ENST00000543643 GCH1-003 54842016-54902807 protein_coding
  ENST00000622544 GCH1-202 54842008-54902824 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000254299ENST00000395514ENST00000395521ENST00000491895ENST00000536224ENST00000622544
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000254299 1.725±0.00 N/A 1.475±0.00 0.158±0.00 N/A 1.134±0.35 0.418±0.27 3.380±2.13 14.074±0.00 1.941±0.00 0.123±0.00 2.046±1.15 1.212±0.38 1.539±0.00
ENST00000395514 N/A N/A N/A N/A N/A 1.799±0.00 0.274±0.00 2.115±0.00 5.674±5.52 7.574±0.00 0.166±0.00 N/A 0.543±0.03 1.672±0.00
ENST00000395521 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.564±0.00 N/A N/A N/A
ENST00000491895 N/A 1.232±0.00 N/A N/A N/A N/A N/A N/A N/A 7.780±0.00 N/A N/A 0.779±0.00 N/A
ENST00000536224 N/A N/A N/A 0.065±0.00 N/A N/A N/A 5.893±0.00 N/A N/A 1.224±0.00 0.843±0.32 1.292±0.00 N/A
ENST00000622544 N/A 1.518±0.00 N/A 0.911±0.00 1.605±0.58 N/A N/A 2.760±0.00 N/A N/A N/A N/A N/A 1.820±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000009 CIL_000009_0002 CGP 14:54567097-54902852
CIL_000005 CIL_000005_0002 CGP 14:54842008-55027105

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003934 IDA:IEA GTP cyclohydrolase I activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005525 IDA GTP binding
GO:0005634 IDA nucleus
GO:0005737 IDA:IEA cytoplasm
GO:0005829 IDA cytosol
GO:0006184 IDA GTP catabolic process
GO:0006461 IEA protein complex assembly
GO:0006729 IMP tetrahydrobiopterin biosynthetic process
GO:0006809 NAS nitric oxide biosynthetic process
GO:0008152 IDA metabolic process
GO:0008217 IMP regulation of blood pressure
GO:0008270 IDA zinc ion binding
GO:0014916 IEA regulation of lung blood pressure
GO:0030742 IEA GTP-dependent protein binding
GO:0031410 IDA cytoplasmic vesicle
GO:0031965 IDA nuclear membrane
GO:0032496 IDA response to lipopolysaccharide
GO:0034341 IDA response to interferon-gamma
GO:0034612 IDA response to tumor necrosis factor
GO:0035998 IEA 7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0042311 IEA vasodilation
GO:0042416 IDA dopamine biosynthetic process
GO:0042559 IDA pteridine-containing compound biosynthetic process
GO:0042803 IPI protein homodimerization activity
GO:0043234 IDA protein complex
GO:0044281 TAS small molecule metabolic process
GO:0045776 IEA negative regulation of blood pressure
GO:0046209 TAS nitric oxide metabolic process
GO:0046654 IEA tetrahydrofolate biosynthetic process
GO:0048265 ISS response to pain
GO:0050662 IEA coenzyme binding
GO:0050884 IMP neuromuscular process controlling posture
GO:0050999 TAS regulation of nitric-oxide synthase activity
GO:0051000 IDA positive regulation of nitric-oxide synthase activity
GO:0051066 IEA dihydrobiopterin metabolic process
GO:0051260 IDA protein homooligomerization
GO:0051291 IEA protein heterooligomerization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070453 gch1 GTP cyclohydrolase 1 protein_coding Danio_rerio
ENSMUSG00000037580 Gch1 GTP cyclohydrolase 1 protein_coding Mus_musculus

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