C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NLR family, CARD domain containing 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000039193 Nlrc4 10090 - 17:74426295-74459108 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000052124 Nlrc4-201 74426295-74459108 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000052124
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000052124 0.185±0.05 0.101±0.05 0.085±0.00 0.029±0.01 0.481±0.23 2.720±0.83 0.083±0.03 0.115±0.07 0.101±0.09 0.372±0.11 0.043±0.03 0.174±0.08 0.165±0.10 0.133±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000MX CIL_0000MX_0002 CGP 17:74395608-74459108
CIL_0000MY CIL_0000MY_0002 CGP 17:74426295-74500277

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002218 IMP activation of innate immune response
GO:0005515 IEA protein binding
GO:0005524 ISS ATP binding
GO:0005829 IDA cytosol
GO:0006919 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 IMP inflammatory response
GO:0016045 ISS detection of bacterium
GO:0042742 ISS defense response to bacterium
GO:0042802 IEA identical protein binding
GO:0042803 ISS protein homodimerization activity
GO:0042981 IMP regulation of apoptotic process
GO:0043065 IEA positive regulation of apoptotic process
GO:0043281 IMP regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 IEA innate immune response
GO:0050702 ISS interleukin-1 beta secretion
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051260 IDA protein homooligomerization
GO:0070269 IMP pyroptosis
GO:0072557 IDA IPAF inflammasome complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000091106 NLRC4 NLR family, CARD domain containing 4 protein_coding Homo_sapiens

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